Functional characterization of the dural sinuses as a neuroimmune interface

Justin Rustenhoven, Antoine Drieu, Tornike Mamuladze, +21

Cell

NeurophysiologyNeuroanatomySynaptic TransmissionMedicineImmunology +7

Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma

Andrea Cugurra, Tornike Mamuladze, Justin Rustenhoven, +14

Science

Cell ReservoirsInnate Immune SystemImmunologyVertebral Bone MarrowInnate Immunity +24

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nobuhiro Nakamoto, Nobuo Sasaki, Ryo Aoki, +19

Nature Microbiology

InflammationDysbiosisAutoimmune DiseaseMucosal ImmunologyImmunology +11

Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells

Masahiro Okada, Mitsuhiro Kanamori, Kazue Someya, +2

Epigenetics & Chromatin

Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy

Taisuke Kondo, Rimpei Morita, Yuumi Okuzono, +10

Nature Communications

Interaction between a Domain of the Negative Regulator of the Ras-ERK Pathway, SPRED1 Protein, and the GTPase-activating Protein-related Domain of Neurofibromin Is Implicated in Legius Syndrome and Neurofibromatosis Type 1

Yasuko Hirata, Hilde Brems, Mayu Suzuki, +8

Journal of Biological Chemistry

Role of scavenger receptors as damage-associated molecular pattern receptors in Toll-like receptor activation

Kyoko Komai, Takashi Shichita, Minako Ito, +3

International Immunology

Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer’s disease

Ryusei Kaneko, Ako Matsui, Mahiro Watanabe, +11

Inflammation and Regeneration

Nr4a Receptors Regulate Development and Death of Labile Treg Precursors to Prevent Generation of Pathogenic Self-Reactive Cells

Takashi Sekiya, Sana Hibino, Keita Saeki, +2

Cell Reports

Labile Treg PrecursorsPathogenic Self-reactive CellsLymphocyte DevelopmentT-regulatory CellImmunology +16

Reprogramming of Th1 cells into regulatory T cells through rewiring of the metabolic status

Mitsuhiro Kanamori, Hiroko Nakatsukasa, Minako Ito, +2

International Immunology

Lymphocyte DevelopmentTh1reg CellsT-regulatory CellImmunologyImmune Regulation +26