Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation

Guochun Jiang, Érica Araújo Mendes, Philipp Kaiser, +9

PLoS Pathogens

Latent Hiv ExpressionImmunologySynergistic ReactivationImmunotherapeuticsAntiviral Drug +18

HIV latency is reversed by ACSS2-driven histone crotonylation

Guochun Jiang, Don X. Nguyen, Nancie M. Archin, +9

Journal of Clinical Investigation

Histone ModificationsChromatinViral LatencyHiv LatencyChromatin Remodeling +13

HIV-1 Populations in Semen Arise through Multiple Mechanisms

Jeffrey A. Anderson, Li‐Hua Ping, Oliver Dibben, +12

PLoS Pathogens

Viral ReplicationGeneticsImmunologyViral DynamicSemen Analysis +17

Brain microglia serve as a persistent HIV reservoir despite durable antiretroviral therapy

Yuyang Tang, Antoine Chaillon, Sara Gianella, +25

Journal of Clinical Investigation

ImmunologyPersistent ReservoirSocial SciencesNeuroinflammationDurable Antiretroviral Therapy +16

Comparison of Viral Env Proteins from Acute and Chronic Infections with Subtype C Human Immunodeficiency Virus Type 1 Identifies Differences in Glycosylation and CCR5 Utilization and Suggests a New Strategy for Immunogen Design

Li-Hua Ping, Sarah Joseph, Jeffrey A. Anderson, +36

Journal of Virology

Viral Env ProteinsImmunologyCcr5 UtilizationViral DynamicImmunotherapy +15

Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cδ–NF-κB signaling

Guochun Jiang, Érica Araújo Mendes, Philipp Kaiser, +9

AIDS

Deficiency of Niemann-Pick Type C-1 Protein Impairs Release of Human Immunodeficiency Virus Type 1 and Results in Gag Accumulation in Late Endosomal/Lysosomal Compartments

Yuyang Tang, Ihid Carneiro Leão, Ebony M. Coleman, +2

Journal of Virology

Proteinlipid InteractionGag AccumulationImmunologyPathologyLipid Movement +14

Endogenous Retroviral Envelope Syncytin Induces HIV-1 Spreading and Establishes HIV Reservoirs in Placenta

Yuyang Tang, Beverly Woodward, Lorena Pastor, +6

Cell Reports

Viral ReplicationSystems BiologyEstablishes Hiv ReservoirsMedicineHuman Retrovirus +13

HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for Establishing Viral Replication Early in Infection

Guochun Jiang, Clarissa Santos Rocha, Lauren A. Hirao, +5

mBio

Slowly Declining Levels of Viral RNA and DNA in DNA/Recombinant Modified Vaccinia Virus Ankara-Vaccinated Macaques with Controlled Simian-Human Immunodeficiency Virus SHIV-89.6P Challenges

Yuyang Tang, François Villinger, Silvija I. Staprans, +4

Journal of Virology