Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia

Märt Toots, Jeong-Joong Yoon, Robert M. Cox, +14

Science Translational Medicine

Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses

Jeong-Joong Yoon, Märt Toots, Sujin Lee, +18

Antimicrobial Agents and Chemotherapy

Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model

Märt Toots, Jeong-Joong Yoon, M. N. Hart, +3

Translational research

VaccinationFerret ModelTherapeutic EfficacyExperimental TherapeuticInfluenza Vaccine +4

4′-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication

Julien Sourimant, Carolin M. Lieber, Megha Aggarwal, +12

Science

Oral AntiviralRespiratory Virus ImmunityViral Polymerase StructureViral Polymerase MechanismImmunology +15

Tetherin/BST-2 Is Essential for the Formation of the Intracellular Virus-Containing Compartment in HIV-Infected Macrophages

Hin Chu, Jaang-Jiun Wang, Mingli Qi, +6

Cell Host & Microbe

InflammationHiv-infected MacrophagesHuman RetrovirusImmunologyViral Pathogenesis +8

Nonpeptide Inhibitors of Measles Virus Entry

Aiming Sun, Andrew Prussia, Weiqiang Zhan, +10

Journal of Medicinal Chemistry

Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: Synthesis and in vitro evaluation

Aiming Sun, Nizal Chandrakumar, Jeong-Joong Yoon, +2

Bioorganic & Medicinal Chemistry Letters

Viral ReplicationBiochemistryNatural SciencesNon-nucleoside InhibitorsAntiviral Drug Development +5

4'-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication.

Julien Sourimant, Carolin M. Lieber, Megha Aggarwal, +12

PubMed

Nonnucleoside Inhibitor of Measles Virus RNA-Dependent RNA Polymerase Complex Activity

Laura K. White, Jeong-Joong Yoon, Jin K. Lee, +5

Antimicrobial Agents and Chemotherapy

Potent Host-Directed Small-Molecule Inhibitors of Myxovirus RNA-Dependent RNA-Polymerases

Stefanie A. Krumm, John M. Ndungu, Jeong-Joong Yoon, +5

PLoS ONE

Viral ReplicationSynthetic VirologyNeurovirologyMedicineImmunology +12