Small-molecule WNK inhibition regulates cardiovascular and renal function

Ken Yamada, Hyi-Man Park, Dean F. Rigel, +58

Nature Chemical Biology

Molecular PhysiologyKidney ResearchMedicinePhysiologyPharmacology +6

Total Synthesis of (+)-Isoschizandrin Utilizing a Samarium(II) Iodide-Promoted 8-Endo Ketyl−Olefin Cyclization

Gary A. Molander, Kelly M. George, Lauren G. Monovich

The Journal of Organic Chemistry

Total Synthesis of (−)-Steganone Utilizing a Samarium(II) Iodide Promoted 8-Endo Ketyl−Olefin Cyclization

Lauren G. Monovich, Yvan Le Huérou, Magnus Rönn, +1

Journal of the American Chemical Society

Chemical Engineering8-Endo Ketyl−olefin CyclizationEngineeringRing SystemHeterocyclic +13

Optimization of Halopemide for Phospholipase D2 inhibition

Lauren G. Monovich, Benjamin Mugrage, Elizabeth Quadros, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineMechanism Of ActionPharmacologyPhospholipase D2 Inhibition +2

A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase

Lauren G. Monovich, Richard B. Vega, Erik L. Meredith, +9

FEBS Letters

Discovery of Potent, Selective, and Orally Active Carboxylic Acid Based Inhibitors of Matrix Metalloproteinase-13

Lauren G. Monovich, Rubén Tommasi, Roger A. Fujimoto, +33

Journal of Medicinal Chemistry

Active Carboxylic AcidType Ii CollagenChemical BiologyOsteoporosisMusculoskeletal Research +17

Identification of Orally Available Naphthyridine Protein Kinase D Inhibitors

Erik L. Meredith, Ophelia Ardayfio, Kimberly Beattie, +31

Journal of Medicinal Chemistry

Medicinal ChemistryHeart FailureBiochemistryMedicineNatural Sciences +9

Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors

Erik L. Meredith, Gary M. Ksander, Lauren G. Monovich, +15

ACS Medicinal Chemistry Letters

Identification of a PCSK9-LDLR disruptor peptide with in vivo function

Margaret E. Brousseau, Kevin B. Clairmont, Glen Spraggon, +39

Cell chemical biology

InflammationSignal TransductionPeptide LibraryImmunologyPcsk9-ldlr Disruptor Peptide +5

Identification of Potent and Selective Amidobipyridyl Inhibitors of Protein Kinase D

Erik L. Meredith, Kimberly Beattie, Robin Burgis, +25

Journal of Medicinal Chemistry

Heart MorphologyCardiac MuscleHeart FailureDrug TargetChemical Biology +17