Marcus Weinguny

Systematic use of synthetic 5′-UTR RNA structures to tune protein translation improves yield and quality of complex proteins in mammalian cell factories

Peter Eisenhut, Aman Mebrahtu, Mona Moradi Barzadd et al. · Nucleic Acids Research · 2020 · 41 citations · Full text

Engineering, Molecular Regulation, Molecular Biology +23

Directed evolution approach to enhance efficiency and speed of outgrowth during single cell subcloning of Chinese Hamster Ovary cells

Marcus Weinguny, Gerald Klanert, Peter Eisenhut et al. · Computational and Structural Biotechnology Journal · 2020 · 30 citations · Full text

Oocyte, Genetics, Cell Culture +23

Subcloning induces changes in the DNA‐methylation pattern of outgrowing Chinese hamster ovary cell colonies

Marcus Weinguny, Gerald Klanert, Peter Eisenhut et al. · Biotechnology Journal · 2021 · 25 citations · Full text

Epigenetic Change, Genetics, Dna Methylation +20

Random epigenetic modulation of CHO cells by repeated knockdown of DNA methyltransferases increases population diversity and enables sorting of cells with higher production capacities

Marcus Weinguny, Peter Eisenhut, Gerald Klanert et al. · Biotechnology and Bioengineering · 2020 · 24 citations · Full text

Epigenetic Change, Genetics, Dna Methylation +27

A cross-species whole genome siRNA screen in suspension-cultured Chinese hamster ovary cells identifies novel engineering targets

Gerald Klanert, Daniel Jiménez Fernández, Marcus Weinguny et al. · Scientific Reports · 2019 · 23 citations · Full text