Small-Molecule Inhibition of TNF-α

Molly M. He, Annemarie Stroustrup, Johan D. Oslob, +17

Science

ImmunologyCell DeathMolecular BiologyInflammationTnf-alpha Subunits +15

Selectivity of BAFF/BLyS and APRIL for Binding to the TNF Family Receptors BAFFR/BR3 and BCMA

Eric S. Day, Teresa G. Cachero, Fang Qian, +5

Biochemistry

ImmunologyImmune RegulationImmunologic MechanismOpposite SelectivityImmunotherapy +14

Enhanced Potency of Human Sonic Hedgehog by Hydrophobic Modification

Frederick R. Taylor, Dingyi Wen, Ellen A. Garber, +13

Biochemistry

Tissue EngineeringProteinlipid InteractionEngineeringHydrophobic ModificationsBiofabrication +15

Mapping Sonic Hedgehog-Receptor Interactions by Steric Interference

R. Blake Pepinsky, Paul Rayhorn, Eric S. Day, +6

Journal of Biological Chemistry

Comparison of Soluble Decoy IgG Fusion Proteins of BAFF-R and BCMA as Antagonists for BAFF

Marc R. Pelletier, Jeffrey S. Thompson, Fang Qian, +12

Journal of Biological Chemistry

Comparison of Binding Characteristics and In Vitro Activities of Three Inhibitors of Vascular Endothelial Growth Factor A

Jihong Yang, Xiangdan Wang, Germaine Fuh, +9

Molecular Pharmaceutics

Comparative analyses of a small molecule/enzyme interaction by multiple users of Biacore technology

Michelle J. Cannon, Giuseppe A. Papalia, Iva Navrátilová, +36

Analytical Biochemistry

BiochemistryNatural SciencesBiocatalysisBioanalysisEnzyme Catalysis +9

Formation of Virus-like Clusters Is an Intrinsic Property of the Tumor Necrosis Factor Family Member BAFF (B Cell Activating Factor)

Teresa G. Cachero, Ian M. Schwartz, Fang Qian, +12

Biochemistry

Viral PathogenesisImmunologyPathologyMolecular BiologyB Cell Development +15

Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism

Laura Silvian, Jessica E. Friedman, Kathy Strauch, +6

ACS Chemical Biology

Protein AssemblyImmune RegulationImmunologyCell DeathMolecular Biology +27

Development of an Fn14 agonistic antibody as an anti-tumor agent

Jennifer S. Michaelson, Aldo Amatucci, Rebecca K. Kelly, +13

mAbs

Tumor BiologyOncologyTnf Family LigandMedicineTumor Growth +13