Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

Hervé Tiriac, Pascal Belleau, Dannielle D. Engle, +67

Cancer Discovery

The mutational landscape of human somatic and germline cells

Luiza Moore, Alex Cagan, Tim Coorens, +25

Nature

Somatic VariantGerm CellMutational LandscapeSomatic Cell GeneticsGenetics +1

Inherent mosaicism and extensive mutation of human placentas

Tim Coorens, Thomas R. W. Oliver, Rashesh Sanghvi, +11

Nature

Placental DevelopmentGeneticsMaternal HealthInherent MosaicismPublic Health +3

Extensive phylogenies of human development inferred from somatic mutations

Tim Coorens, Luiza Moore, Philip S. Robinson, +17

Nature

Genetic and chemotherapeutic influences on germline hypermutation

Joanna Kaplanis, Benjamin Ide, Rashesh Sanghvi, +15

Nature

Deep whole-genome sequencing of 3 cancer cell lines on 2 sequencing platforms

Kanika Arora, Minita Shah, Molly Johnson, +9

Scientific Reports

The mutational landscape of human somatic and germline cells

Luiza Moore, Alex Cagan, Tim Coorens, +25

SpermatogenesisBiologyUbiquitous Mutation ProcessesSomatic VariantGerm Cell +13

A recurrent novel <i>MGA–NUTM1</i> fusion identifies a new subtype of high-grade spindle cell sarcoma

Daniel Diolaiti, Filemon S. Dela Cruz, Gunes Gundem, +17

Molecular Case Studies

Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression

Thomas G. Paulson, Patricia C. Galipeau, Kenji Oman, +19

Nature Communications

Characterizing reduced coverage regions through comparison of exome and genome sequencing data across 10 centers

Rashesh Sanghvi, Christian Buhay, Bradford C. Powell, +27

Genetics in Medicine

BioinformaticsLong-read SequencingMolecular EcologyGenome Sequencing DataNext-generation Sequencing +10