Eleanor K. H. Allen

Translating slow-binding inhibition kinetics into cellular and in vivo effects

Grant K. Walkup, Zhiping You, Philip L. Ross et al. · Nature Chemical Biology · 2015 · 154 citations · Full text

Medicine, Biochemistry, Pharmacology +14

Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors

Lauren A. Spagnuolo, Sandra Eltschkner, Weixuan Yu et al. · Journal of the American Chemical Society · 2017 · 58 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Characterization of Nicotinamidases: Steady State Kinetic Parameters, Classwide Inhibition by Nicotinaldehydes, and Catalytic Mechanism

Jarrod B. French, Yana Cen, Tracy Vrablik et al. · Biochemistry · 2010 · 55 citations · Full text

Life Sciences, Biochemistry, Microbiology +15

Impact of Target Turnover on the Translation of Drug-Target Residence Time to Time-Dependent Antibacterial Activity

Rajeswari Basu, Nan Wang, Sneha Basak et al. · ACS Infectious Diseases · 2021 · 13 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +14