George A. Cunha

Discovery of<i>N</i>-(4-(3-Amino-1<i>H</i>-indazol-4-yl)phenyl)-<i>N</i>‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitor

Yujia Dai, Kresna Hartandi, Zhiqin Ji et al. · Journal of Medicinal Chemistry · 2007 · 185 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Thienopyrimidine Ureas as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors

Yujia Dai, Yan Guo, Robin R. Frey et al. · Journal of Medicinal Chemistry · 2005 · 152 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Isoindolinone ureas: a novel class of KDR kinase inhibitors

Michael L. Curtin, Robin R. Frey, H. Robin Heyman et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 33 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +10

1,4-Dihydroindeno[1,2-<i>c</i>]pyrazoles with Acetylenic Side Chains as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors with Low Affinity for the hERG Ion Channel

Jürgen Dinges, Daniel H. Albert, Lee D. Arnold et al. · Journal of Medicinal Chemistry · 2007 · 31 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors

Jürgen Dinges, Irini Akritopoulou‐Zanze, Lee D. Arnold et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 23 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16