Neurotrophin secretion from cultured microglia

Kazuyuki Nakajima, Shizuyo Honda, Yoko Tohyama, +3

Journal of Neuroscience Research

Ability of rat microglia to uptake extracellular glutamate

Kazuyuki Nakajima, Yoko Tohyama, Shinichi Kohsaka, +1

Neuroscience Letters

MedicineRat MicrogliaBrain-immune InteractionNeuroscienceNeuroimmunology +2

Ceramide activates microglia to enhance the production/secretion of brain‐derived neurotrophic factor (BDNF) without induction of deleterious factors <i>in vitro</i>

Kazuyuki Nakajima, Yoko Tohyama, Shinichi Kohsaka, +1

Journal of Neurochemistry

Neuronal regulation by which microglia enhance the production of neurotrophic factors for GABAergic, catecholaminergic, and cholinergic neurons

Kazuyuki Nakajima, Yoko Tohyama, Shyuichi Maeda, +2

Neurochemistry International

Neuronal RegulationHealth SciencesNeurophysiologyMedicinePhysiology +9

Protein kinase Cα requirement in the activation of p38 mitogen-activated protein kinase, which is linked to the induction of tumor necrosis factor α in lipopolysaccharide-stimulated microglia

Kazuyuki Nakajima, Yoko Tohyama, Shinichi Kohsaka, +1

Neurochemistry International

InflammationSignal TransductionCα RequirementMedicineImmune Regulation +9

Phylogenetic relation of lungfish indicated by the amino acid sequence of myelin DM20

Yoko Tohyama, Tomomi Ichimiya, Hiromi Kasama‐Yoshida, +5

Molecular Brain Research

BiologyDevelopmental BiologyPhylogenetic RelationNeuroanatomyMedicine +8

Activation of microglia by endotoxin suppresses the secretion of glial cell line–derived neurotrophic factor (GDNF) through the action of protein kinase Cα (PKCα) and mitogen‐activated protein kinases (MAPKS)

Yuichi Matsushita, Kazuyuki Nakajima, Yoko Tohyama, +2

Journal of Neuroscience Research

ImmunologyGlial CellProtein Kinase CαNonstimulated Microglia ReleaseNeuroinflammation +15

Nonparticipation of nuclear factor kappa B (NFκB) in the signaling cascade of c-Jun N-terminal kinase (JNK)- and p38 mitogen-activated protein kinase (p38MAPK)-dependent tumor necrosis factor alpha (TNFα) induction in lipopolysaccharide (LPS)-stimulated microglia

Miyuki Uesugi, Kazuyuki Nakajima, Yoko Tohyama, +2

Brain Research

InflammationNeuroinflammationCytokineSignal TransductionImmune Cell Development +13

Differential suppression of endotoxin-inducible inflammatory cytokines by nuclear factor kappa B (NFκB) inhibitor in rat microglia

Kazuyuki Nakajima, Yuichi Matsushita, Yoko Tohyama, +2

Neuroscience Letters

InflammationCytokineDifferential SuppressionAnti-inflammatoryLung Inflammation +10

Characteristic response of astrocytes to plasminogen/plasmin to upregulate transforming growth factor beta 3 (TGFβ3) production/secretion through proteinase-activated receptor-1 (PAR-1) and the downstream phosphatidylinositol 3-kinase (PI3K)-Akt/PKB signaling cascade

Shyuichi Maeda, Kazuyuki Nakajima, Yoko Tohyama, +1

Brain Research

Developmental BiologySignal TransductionMolecular PhysiologySignaling PathwayReceptor Tyrosine Kinase +9