Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation

Weizhe Zhong, Zhuqing Rao, Jian Xu, +9

Aging Cell

Aging aggravated liver ischemia and reperfusion injury by promoting STING‐mediated NLRP3 activation in macrophages

Weizhe Zhong, Zhuqing Rao, Jianhua Rao, +7

Aging Cell

Sting‐mediated Nlrp3 ActivationInnate Immune SystemImmunologyCell DeathAged Macrophages +20

MGP promotes CD8⁺ T cell exhaustion by activating the NF-κB pathway leading to liver metastasis of colorectal cancer

Dawei Rong, Guangshun Sun, Zhiying Zheng, +12

International Journal of Biological Sciences

Macrophage STING signaling promotes NK cell to suppress colorectal cancer liver metastasis via 4-1BBL/4-1BB co-stimulation

Yu Sun, Haoran Hu, Zheng Liu, +10

Journal for ImmunoTherapy of Cancer

m6A modification of circHPS5 and hepatocellular carcinoma progression through HMGA2 expression

Dawei Rong, Fan Wu, Lu Chen, +10

Molecular Therapy — Nucleic Acids

Dexmedetomidine preconditioning alleviated murine liver ischemia and reperfusion injury by promoting macrophage M2 activation via PPARγ/STAT3 signaling

Haoming Zhou, Jie Sun, Weizhe Zhong, +5

International Immunopharmacology

Aging aggravated liver ischemia and reperfusion injury by promoting hepatocyte necroptosis in an endoplasmic reticulum stress-dependent manner

Weizhe Zhong, Xiaowei Wang, Zhuqing Rao, +6

Annals of Translational Medicine

Combined ischemic and rapamycin preconditioning alleviated liver ischemia and reperfusion injury by restoring autophagy in aged mice

Tao Jiang, Feng Zhan, Zhuqing Rao, +7

International Immunopharmacology

MitophagyRapamycin PreconditioningCell DeathPathologyOxidative Stress +18

Dexmedetomidine attenuates sepsis-associated acute lung injury by regulating macrophage efferocytosis through the ROS/ADAM10/AXL pathway

Fei Li, Yan Bai, Zhu Guan, +5

International Immunopharmacology

Acute Lung InjuryInflammationTranslational MedicineAnti-inflammatoryInflammatory Lung Disease +8

N-acetylcysteine alleviates liver injury by suppressing macrophage-mediated inflammatory response post microwave ablation

Haoming Zhou, Yu Sun, Qingyuan Wang, +5

International Immunopharmacology