In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges

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Science

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CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

Matouš Hrdinka, Berthe Katrine Fiil, Mattia Zucca, +8

Cell Reports

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

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Molecular Cell

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Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann–Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease

Tobias Schwerd, Sumeet Pandey, Huei‐Ting Yang, +25

Gut

Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

Emma J. Fenech, Federica Lari, Philip D. Charles, +8

eLife

Innate Immune SystemImmunologyMolecular BiologyImmunologic MechanismSterol Homeostasis +22

In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges

Beata Turoňová, Mateusz Sikora, Christoph Schürmann, +15

Virus StructureVaccine DevelopmentViral PathogenesisImmunologyMolecular Biology +10

Human ZBP1 induces cell death‐independent inflammatory signaling via RIPK3 and RIPK1

Ruoshi Peng, Chris Kedong Wang, Xuan Wang‐Kan, +15

EMBO Reports

ApoptosisImmunologyImmune RegulationCell DeathImmunologic Mechanism +15

Ubiquitin Binding by a CUE Domain Regulates Ubiquitin Chain Formation by ERAD E3 Ligases

Katrin Bagola, Maximilian von Delbrück, Gunnar Dittmar, +5

Molecular Cell

Protein Quality ControlSignal TransductionSignaling PathwayCell RegulationMolecular Regulation +6

Protein Quality Control: On IPODs and Other JUNQ

Katrin Bagola, Thomas Sommer

Current Biology

Protein Quality ControlBiochemistryNatural SciencesBiotechnologyProtein Refolding +3

The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63‐branched ubiquitin chains

Lukas Pluska, Ernst Jarosch, Henrik Zauber, +9

The EMBO Journal