John C. Clapham

Superoxide activates mitochondrial uncoupling proteins

Karim S. Echtay, Damien Roussel, Julie St‐Pierre et al. · Nature · 2002 · 1.4K citations

Biochemistry, Mitochondrial Function, Natural Sciences +5

Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

John C. Clapham, Jonathan R. S. Arch, Helen Chapman et al. · Nature · 2000 · 612 citations

Muscle Function, Kinesiology, Molecular Physiology +10

Hypothalamic orexin expression: modulation by blood glucose and feeding.

Xue Cai, Peter Widdowson, Joanne A. Harrold et al. · Diabetes · 1999 · 317 citations

Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma.

Paul Young, Derek R. Buckle, Barrie C. C. Cantello et al. · PubMed · 1998 · 230 citations

Insulin Sensitizer Rosiglitazone, Lipid Peroxidation, Human Adipocytes +16

Peroxisome Proliferator-Activated Receptor-γ Agonist, Rosiglitazone, Protects Against Nephropathy and Pancreatic Islet Abnormalities in Zucker Fatty Rats

Robin E. Buckingham, Kamal Albarazanji, C. D. N. Toseland et al. · Diabetes · 1998 · 205 citations

Hypertension, Zucker Rats, Insulin Signaling +24