Despina Smirlis

Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death

Despina Smirlis, Michael Duszenko, Effie Scoulica et al. · Parasites & Vectors · 2010 · 119 citations · Full text

<i>Leishmania</i> Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification

Giovanni Bussotti, Evi Gouzelou, Mariana Côrtes Boité et al. · mBio · 2018 · 109 citations · Full text

Orphan Receptor Promiscuity in the Induction of Cytochromes P450 by Xenobiotics

Despina Smirlis, Roongsiri Muangmoonchai, Mina Edwards et al. · Journal of Biological Chemistry · 2001 · 106 citations · Full text

Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1

Roongsiri Muangmoonchai, Despina Smirlis, Siew Cheng Wong et al. · Biochemical Journal · 2001 · 88 citations · Full text

6-Br-5methylindirubin-3′oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: Exploitation of GSK-3 for treating leishmaniasis

Evangelia Xingi, Despina Smirlis, Vassilios Myrianthopoulos et al. · International Journal for Parasitology · 2009 · 74 citations

Induces Apoptosis-like Death, Necroptosis, Apoptosis +9