W.S. Eng

Inhibition of the <i>Escherichia coli</i> 6-Oxopurine Phosphoribosyltransferases by Nucleoside Phosphonates: Potential for New Antibacterial Agents

Dianne T. Keough, Dana Hocková, Dominik Rejman et al. · Journal of Medicinal Chemistry · 2013 · 43 citations

Life Sciences, Biochemistry, Pharmacology +11

First Crystal Structures of <i>Mycobacterium tuberculosis</i> 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity

W.S. Eng, Dana Hocková, Petr Špaček et al. · Journal of Medicinal Chemistry · 2015 · 40 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase

W.S. Eng, Dominik Rejman, Radek Pohl et al. · European Journal of Medicinal Chemistry · 2018 · 16 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +9

Synthesis, conformational studies, and biological properties of phosphonomethoxyethyl derivatives of nucleobases with a locked conformation via a pyrrolidine ring

Radek Pohl, Lenka Poštová Slavětínská, W.S. Eng et al. · Organic & Biomolecular Chemistry · 2015 · 12 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Oligomeric state of hypoxanthine−guanine phosphoribosyltransferase from Mycobacterium tuberculosis

W.S. Eng, Dianne T. Keough, Dana Hocková et al. · Biochimie · 2017 · 11 citations

Life Sciences, Biochemistry, Microbiology +8