Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration

Jian Chen, Jun-Jun Xie, Mengyun Jin, +12

Cell Death and Disease

Small molecule natural compound agonist of SIRT3 as a therapeutic target for the treatment of intervertebral disc degeneration

Jianle Wang, Majid Nisar, Chongan Huang, +14

Experimental & Molecular Medicine

Melatonin protects endothelial progenitor cells against AGE-induced apoptosis via autophagy flux stimulation and promotes wound healing in diabetic mice

Haiming Jin, Zengjie Zhang, Chengui Wang, +10

Experimental & Molecular Medicine

Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition

Yu Chen, Yanqing Wu, Hongxue Shi, +8

Journal of Cellular and Molecular Medicine

MitophagyApoptosis InhibitionApoptosisCell DeathCell Death Mechanisms +19

Hydrogen sulfide protects against endoplasmic reticulum stress and mitochondrial injury in nucleus pulposus cells and ameliorates intervertebral disc degeneration

Daoliang Xu, Haiming Jin, Jianxia Wen, +8

Pharmacological Research

Reductive StressMitochondrial FunctionBiochemistryLipid PeroxidationPhysiology +10

The Histone Demethylase JMJD2C Is Stage-Specifically Expressed in Preimplantation Mouse Embryos and Is Required for Embryonic Development1

Jianle Wang, Miao Zhang, Yu Zhang, +5

Biology of Reproduction

Preimplantation Mouse EmbryosEpigenetic ChangeGeneticsDna MethylationHistone Demethylase Jmjd2c +20

SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis

Jianle Wang, Ke Wang, Chongan Huang, +11

International Journal of Biological Sciences

BRD4 inhibition attenuates inflammatory response in microglia and facilitates recovery after spinal cord injury in rats

Jianle Wang, Jiaoxiang Chen, Haiming Jin, +12

Journal of Cellular and Molecular Medicine

InflammationAnti-inflammatorySpinal Cord InjuryMedicineImmunology +12

BRD4 inhibition regulates MAPK, NF‐κB signals, and autophagy to suppress MMP‐13 expression in diabetic intervertebral disc degeneration

Jianle Wang, Jianing Hu, Ximiao Chen, +10

The FASEB Journal

Berberine suppresses apoptosis and extracellular matrix (ECM) degradation in nucleus pulposus cells and ameliorates disc degeneration in a rodent model

Yu Chen, Zengming Zheng, Jianle Wang, +11

International Journal of Biological Sciences