Sofiya Leshchenko

High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-peptide Inhibitor (UIC-94017) Active Against Multi-drug-resistant Clinical Strains

Yunfeng Tie, Péter Boross, Yuan‐Fang Wang et al. · Journal of Molecular Biology · 2004 · 225 citations

Life Sciences, Biochemistry, Medicinal Chemistry +12

Structure-Based Design of Novel HIV-1 Protease Inhibitors To Combat Drug Resistance

Arun K. Ghosh, P. Sridhar, Sofiya Leshchenko et al. · Journal of Medicinal Chemistry · 2006 · 155 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114

Andrey Kovalevsky, Fengling Liu, Sofiya Leshchenko et al. · Journal of Molecular Biology · 2006 · 145 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

Effectiveness of Nonpeptide Clinical Inhibitor TMC-114 on HIV-1 Protease with Highly Drug Resistant Mutations D30N, I50V, and L90M

Andrey Kovalevsky, Yunfeng Tie, Fengling Liu et al. · Journal of Medicinal Chemistry · 2006 · 143 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Stereoselective Photochemical 1,3-Dioxolane Addition to <i>5-</i>Alkoxymethyl-2(5<i>H</i>)-furanone:  Synthesis of Bis-tetrahydrofuranyl Ligand for HIV Protease Inhibitor UIC-94017 (TMC-114)

Arun K. Ghosh, Sofiya Leshchenko, Marcus W. Noetzel · The Journal of Organic Chemistry · 2004 · 134 citations

Pharmacy, Chemistry, Medicinal Chemistry +15