Rapid determination of quaternary protein structures in complex biological samples

Simon Hauri, Hamed Khakzad, Lotta Happonen, +3

Nature Communications

De novo protein design by inversion of the <scp>AlphaFold</scp> structure prediction network

Casper A. Goverde, Benedict Wolf, Hamed Khakzad, +2

Protein Science

Structural BioinformaticsBiomolecular Structure PredictionProtein FoldingNatural SciencesComputational Biology +11

Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2

Wael Bahnan, Sebastian Wrighton, Martin Sundwall, +19

Frontiers in Immunology

Spike-specific AntibodiesImmune ActivationDose-dependent InhibitionHumoral ResponseImmunology +12

A quantitative Streptococcus pyogenes–human protein–protein interaction map reveals localization of opsonizing antibodies

Lotta Happonen, Simon Hauri, Gabriel Svensson Birkedal, +9

Nature Communications

Streptococcus pyogenes Forms Serotype- and Local Environment-Dependent Interspecies Protein Complexes

Sounak Chowdhury, Hamed Khakzad, Gizem Ertürk, +6

mSystems

Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology

Hamed Khakzad, Lotta Happonen, Yasaman Karami, +6

PLoS Computational Biology

Human Immunoglobulin GMicrobial PathogensProtein AssemblyBiomolecular Structure PredictionStructural Bioinformatics +23

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune function

Wael Bahnan, Lotta Happonen, Hamed Khakzad, +12

EMBO Molecular Medicine

The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms

Mahmudul Hasan, Hamed Khakzad, Lotta Happonen, +9

Chemical Science

In vivo Cross-Linking MS of the Complement System MAC Assembled on Live Gram-Positive Bacteria

Hamed Khakzad, Lotta Happonen, Guy Tran Van Nhieu, +2

Frontiers in Genetics

De novo protein design by inversion of the AlphaFold structure prediction network

Casper A. Goverde, Benedict Wolf, Hamed Khakzad, +2

EngineeringStructural BioinformaticsBiomolecular Structure PredictionGeneticsMolecular Biology +14