Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice

Stephan E. Lehnart, Marco Mongillo, Andrew M. Bellinger, +11

Journal of Clinical Investigation

The nitrodibenzofuran chromophore: a new caging group for ultra-efficient photolysis in living cells

Atsuya Momotake, Nicolas Lindegger, Ernst Niggli, +2

Nature Methods

Nitrodibenzofuran ChromophoreEngineeringPhotochemistryMechanistic PhotochemistryPhotobiology +7

Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice

Jian Shan, Alexander Kushnir, Matthew J. Betzenhauser, +7

Journal of Clinical Investigation

Cardiac MuscleSynaptic TransmissionNeurotransmitterCardiovascular FunctionSynaptic Signaling +22

Preliminary safety and efficacy of first-line pertuzumab combined with trastuzumab and taxane therapy for HER2-positive locally recurrent or metastatic breast cancer (PERUSE)

Thomas Bachelot, Eva Ciruelos, Fabio Puglisi, +288

Annals of Oncology

Metastatic Breast CancerBreast OncologyMedicinePathologyPreliminary Safety +5

Safety of trastuzumab emtansine (T-DM1) in patients with HER2-positive advanced breast cancer: Primary results from the KAMILLA study cohort 1

Filippo Montemurro, Antonio Antón, Rachel Wuerstlein, +8

European Journal of Cancer

Tumor BiologyBreast OncologyMedicinePrimary ResultsPathology +5

Altered Na⁺Channels Promote Pause-Induced Spontaneous Diastolic Activity in Long QT Syndrome Type 3 Myocytes

Sandra Fredj, Nicolas Lindegger, Kevin J. Sampson, +2

Circulation Research

Paradoxical SR Ca²⁺ release in guinea‐pig cardiac myocytes after β‐adrenergic stimulation revealed by two‐photon photolysis of caged Ca²⁺

Nicolas Lindegger, Ernst Niggli

The Journal of Physiology

Cardiac MuscleHeart FailureCardiovascular FunctionOptogeneticsGuinea‐pig Cardiac Myocytes +18

Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazine

Nicolas Lindegger, Brian M. Hagen, Andrew R. Marks, +2

Journal of Molecular and Cellular Cardiology

Heart FailurePhysiologyCa2+ OverloadElectrophysiologyMedicine +3

Pharmacokinetics of the novel dual endothelin receptor antagonist macitentan in subjects with hepatic or renal impairment

Patricia N. Sidharta, Nicolas Lindegger, Ivan Ulč, +1

The Journal of Clinical Pharmacology

Abstract P1-12-10: Safety and efficacy of trastuzumab emtansine (T-DM1) in 399 patients with central nervous system metastases: Exploratory subgroup analysis from the KAMILLA study

Filippo Montemurro, Peter Ellis, Suzette Delaloge, +5

Cancer Research

Breast OncologyCancer ManagementPathologyNeuro-oncologyMetronomic Therapy +14