Human Wild-Type Tau Interacts with wingless Pathway Components and Produces Neurofibrillary Pathology in Drosophila

George R. Jackson, Martina Wiedau‐Pazos, Tzu‐Kang Sang, +4

Neuron

Neurodegenerative DiseasesMolecular NeuroscienceDevelopmental BiologyDevelopmental GeneticsGenetics +8

Dissociation of tau toxicity and phosphorylation: role of GSK-3β, MARK and Cdk5 in a Drosophila model

Shreyasi Chatterjee, Tzu‐Kang Sang, George Lawless, +1

Human Molecular Genetics

A Genomic Screen for Modifiers of Tauopathy Identifies Puromycin-Sensitive Aminopeptidase as an Inhibitor of Tau-Induced Neurodegeneration

Stanislav L. Karsten, Tzu‐Kang Sang, Lauren Gehman, +14

Neuron

Neurodegenerative DiseasesAlzheimer's DiseaseGenomic ScreenGeneticsMolecular Biology +5

A <i>Drosophila</i> Model of Mutant Human Parkin-Induced Toxicity Demonstrates Selective Loss of Dopaminergic Neurons and Dependence on Cellular Dopamine

Tzu‐Kang Sang, Hui-Yun Chang, George Lawless, +6

Journal of Neuroscience

Population structure of the Japanese eel, Anguilla japonica.

Tzu‐Kang Sang, Howard Y. Chang, Christopher T. Chen, +1

Molecular Biology and Evolution

BiologyPhylogeneticsMolecular EcologyComparative GenomicsGenetics +13

Hydrolethalus syndrome is caused by a missense mutation in a novel gene HYLS1

Lisa Mee, Heli Honkala, Outi Kopra, +8

Human Molecular Genetics

Pathogenic VCP/TER94 Alleles Are Dominant Actives and Contribute to Neurodegeneration by Altering Cellular ATP Level in a Drosophila IBMPFD Model

Ya‐Chu Chang, Wan-Tzu Hung, Yun-Chin Chang, +5

PLoS Genetics

Inclusion Body MyopathyGeneticsMolecular BiologyMolecular GeneticsDrosophila Ibmpfd Model +14

Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis

Tzu‐Kang Sang, Chenjian Li, Wen‐Cheng Liu, +4

Human Molecular Genetics

MitophagyMolecular RegulationApoptosisCell DeathMolecular Genetics +14

Reduced neuronal expression of ribose‐5‐phosphate isomerase enhances tolerance to oxidative stress, extends lifespan, and attenuates polyglutamine toxicity in <i>Drosophila</i>

Ching‐Tzu Wang, Yi‐Chun Chen, Y.-T. Wang, +10

Aging Cell

AgingAnti-agingGeneticsRedox BiologyOxidative Stress +16

Eyes closed, a<i>Drosophila</i>p47 homolog, is essential for photoreceptor morphogenesis

Tzu‐Kang Sang, Donald F. Ready

Development