Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

Jacob Levine, Erin F. Simonds, Sean C. Bendall, +13

Cell

Cell LineageDevelopmental BiologyData-driven Phenotypic DissectionMixed-phenotype Acute LeukemiaMedicine +3

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

Sean C. Bendall, Erin F. Simonds, Peng Qiu, +13

Science

viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia

El-ad David Amir, Kara L. Davis, Michelle D. Tadmor, +7

Nature Biotechnology

EngineeringCell DivisionSingle Cell SequencingMedicineSpatial Omics +8

Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE

Peng Qiu, Erin F. Simonds, Sean C. Bendall, +6

Nature Biotechnology

BiologyBioinformaticsEngineeringSingle Cell SequencingMedicine +10

Single-Cell Trajectory Detection Uncovers Progression and Regulatory Coordination in Human B Cell Development

Sean C. Bendall, Kara L. Davis, El-ad David Amir, +6

Cell

Signal TransductionDevelopmental BiologySingle Cell SequencingImmune Cell DevelopmentRegulatory Coordination +11

Normalization of mass cytometry data with bead standards

Rachel Finck, Erin F. Simonds, Astraea Jager, +6

Cytometry Part A

Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators

Bernd Bodenmiller, Eli R. Zunder, Rachel Finck, +8

Nature Biotechnology

Tumor BiologySmall-molecule RegulatorsSignal TransductionTumor MicroenvironmentMedicine +10

Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms

Stephen T. Oh, Erin F. Simonds, Carol D. Jones, +7

Blood

Drugging MYCN through an Allosteric Transition in Aurora Kinase A

W. Clay Gustafson, Justin Meyerowitz, Erin A. Nekritz, +10

Cancer Cell

Signal TransductionMolecular RegulationNatural SciencesReceptor Tyrosine KinaseMolecular Biology +9

Single-Cell Profiling Identifies Aberrant STAT5 Activation in Myeloid Malignancies with Specific Clinical and Biologic Correlates

Nikesh Kotecha, Nikki J. Flores, Jonathan M. Irish, +8

Cancer Cell

Biologic CorrelatesTumor BiologyHematological MalignancyMedicineMixed-phenotype Acute Leukemia +10