Strain history dependence of the nonlinear stress response of fibrin and collagen networks

Stefan Münster, Louise Jawerth, Beverly A. Leslie, +3

Proceedings of the National Academy of Sciences

EngineeringMultiscale MechanicsMechanical EngineeringPersistent LengtheningBiomedical Engineering +21

Thrombin Binds to Soluble Fibrin Degradation Products Where it Is Protected From Inhibition by Heparin-Antithrombin but Susceptible to Inactivation by Antithrombin-Independent Inhibitors

Jeffrey I. Weitz, Beverly A. Leslie, Monika Hudoba

Circulation

Long Range Communication between Exosites 1 and 2 Modulates Thrombin Function

Nicolas S. Petrera, Alan R. Stafford, Beverly A. Leslie, +3

Journal of Biological Chemistry

Molecular BiologyCytoskeletonCellular PhysiologyThrombin VariantHematology +15

Soluble fibrin degradation products potentiate tissue plasminogen activator-induced fibrinogen proteolysis.

Jeffrey I. Weitz, Beverly A. Leslie, Jeffrey S. Ginsberg

Journal of Clinical Investigation

EngineeringImmunologyBiomedical EngineeringSystemic FibrinogenolysisInflammation +16

Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation

Jessica MacQuarrie, Alan R. Stafford, Jonathan W. Yau, +4

Blood

Human tissue-type plasminogen activator releases fibrinopeptides A and B from fibrinogen.

Jeffrey I. Weitz, Moira Cruickshank, Bob Thong, +4

Journal of Clinical Investigation

ImmunologyPharmacotherapyInflammationThrombosisFibrinopeptide Release +15

Identification of the Mechanism Responsible for the Increased Fibrin Specificity of TNK-Tissue Plasminogen Activator Relative to Tissue Plasminogen Activator

R. J. C. Stewart, James C. Fredenburgh, Beverly A. Leslie, +3

Journal of Biological Chemistry

PathologyMechanism ResponsibleCytoskeletonThrombosisProtein Expression +24

Bivalent Binding to γA/γ′-Fibrin Engages Both Exosites of Thrombin and Protects It from Inhibition by the Antithrombin-Heparin Complex

James C. Fredenburgh, Alan R. Stafford, Beverly A. Leslie, +1

Journal of Biological Chemistry

Batroxobin Binds Fibrin with Higher Affinity and Promotes Clot Expansion to a Greater Extent than Thrombin

Trang T. Vu, Alan R. Stafford, Beverly A. Leslie, +3

Journal of Biological Chemistry

Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein

Trang Vu, Ji Zhou, Beverly A. Leslie, +9

Blood