<i>LMO2</i> -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

S. Hacein-Bey-Abina, Christof von Kalle, Manfred Schmidt, +32

Science

Primary ImmunodeficiencyHuman RetrovirusT-regulatory CellImmunologyPathology +12

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

Salima Hacein‐Bey‐Abina, Alexandrine Garrigue, Gary P. Wang, +25

Journal of Clinical Investigation

Viral ReplicationMixed-phenotype Acute LeukemiaImmunologyPathologyRetrovirus-mediated Gene Therapy +21

Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness

Chantal Lagresle‐Peyrou, Emmanuelle Six, Capucine Pïcard, +19

Nature Genetics

Health SciencesProfound Hematopoietic DefectPhysiologyHematologyPathology +5

Long-term T-cell reconstitution after hematopoietic stem-cell transplantation in primary T-cell–immunodeficient patients is associated with myeloid chimerism and possibly the primary disease phenotype

Marina Cavazzana, Frédérique Carlier, Françoise Le Deist, +10

Blood

Long-term immune reconstitution in RAG-1-deficient mice treated by retroviral gene therapy: a balance between efficiency and toxicity

Chantal Lagresle‐Peyrou, F Yates, Michèle Malassis-Séris, +13

Blood

Cytokines and culture medium have a major impact on human in vitro T-cell differentiation

Emmanuelle Six, Alexandrine Garrigue, Delphine Bonhomme, +7

Blood Cells Molecules and Diseases

Induction of protective immunity against Mycobacterium tuberculosis by delivery of ESX antigens into airway dendritic cells

Hui Dong, Ondřej Staněk, Francesc Rudilla, +6

Mucosal Immunology

VaccinationMucosal VaccinationPulmonary TuberculosisTuberculosis PreventionImmunology +8

Loss of p19Arf in a Rag1−/− B-cell precursor population initiates acute B-lymphoblastic leukemia

Julia Hauer, Charles G. Mullighan, Estelle Morillon, +13

Blood