Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes

Samuele Calabrό, Marco Tortoli, Barbara C. Baudner, +6

Vaccine

InflammationMucosal VaccinationAllergyAntigen TransportImmunology +7

The Adjuvants Aluminum Hydroxide and MF59 Induce Monocyte and Granulocyte Chemoattractants and Enhance Monocyte Differentiation toward Dendritic Cells

Anja Seubert, Elisabetta Monaci, Mariagrazia Pizza, +2

The Journal of Immunology

A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines

Luis A. Brito, Michelle Y. Chan, Christine A. Shaw, +18

Molecular Therapy

The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect

Samuele Calabrό, Elaine Tritto, Annamaria Pezzotti, +7

Vaccine

AllergyMedicineAdjuvant EffectMicroemulsionComparable Adjuvant Effect +3

Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake

Frank Liang, Gustaf Lindgren, Kerrie J. Sandgren, +10

Science Translational Medicine

Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88

Anja Seubert, Samuele Calabrό, Laura Santini, +13

Proceedings of the National Academy of Sciences

ImmunologyAdaptor Protein Myd88Oil-in-water Emulsion Mf59Innate ImmunityImmunotherapy +16

Invasion and Persistent Intracellular Colonization of Erythrocytes

Ralf Schülein, Anja Seubert, Christian Gille, +4

The Journal of Experimental Medicine

The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination

Maria Vono, Marianna Taccone, Paola Caccin, +10

Proceedings of the National Academy of Sciences

MF59 Mediates Its B Cell Adjuvanticity by Promoting T Follicular Helper Cells and Thus Germinal Center Responses in Adult and Early Life

Beatris Mastelic Gavillet, Christiane S. Eberhardt, Floriane Auderset, +7

The Journal of Immunology

MF59 and Pam3CSK4 Boost Adaptive Responses to Influenza Subunit Vaccine through an IFN Type I-Independent Mechanism of Action

Elena Caproni, Elaine Tritto, Mario Cortese, +6

The Journal of Immunology

VaccinationCross-protectionSubunit VaccineTrivalent Influenza VaccineAllergy +13