Alexander Astrakhan

Efficient modification of <i>CCR5</i> in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template

Blythe Sather, Guillermo S. Romano Ibarra, Karen Sommer et al. · Science Translational Medicine · 2015 · 226 citations · Full text

megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering

Sandrine Boissel, Jordan Jarjour, Alexander Astrakhan et al. · Nucleic Acids Research · 2013 · 174 citations · Full text

Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development

Alexander Astrakhan, Miyuki Omori, Thuc Nguyen et al. · Nature Immunology · 2007 · 101 citations

Local Increase, Bone Marrow Failure, Autoimmune Disease +11

Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization

Wai-Hang Leung, Joel Gay, Unja Martin et al. · JCI Insight · 2019 · 75 citations · Full text

Extracellular Receptor Dimerization, Adaptive Immune System, T-regulatory Cell +22

Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells

Malika Hale, Baeckseung Lee, Yuchi Honaker et al. · Molecular Therapy — Methods & Clinical Development · 2017 · 70 citations · Full text