Chaetominine, a Cytotoxic Alkaloid Produced by Endophytic <i>Chaetomium</i> sp. IFB-E015

Rui Jiao, Shu Xu, Jun‐Yan Liu, +5

Organic Letters

Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network

Shu Xu, Daniel Hermanson, Surajit Banerjee, +4

Journal of Biological Chemistry

Molecular BiologyHeterocycle ChemistryChemical BiologyRedox BiologyPharmaceutical Chemistry +17

Crystal Structure of 12-Lipoxygenase Catalytic-Domain-Inhibitor Complex Identifies a Substrate-Binding Channel for Catalysis

Shu Xu, Timothy C. Mueser, Lawrence J. Marnett, +1

Structure

Crystal StructureBiochemistryNatural SciencesBiocatalysisSubstrate-binding Channel +5

Poria cocos polysaccharides rescue pyroptosis-driven gut vascular barrier disruption in order to alleviates non-alcoholic steatohepatitis

Haixin Ye, Shuoyi Ma, Zhantu Qiu, +21

Journal of Ethnopharmacology

InflammationMedicineGastroenterologyPathologyNon-alcoholic Steatohepatitis +5

<i>nido</i>‐Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase‐2

Wilma Neumann, Shu Xu, Menyhárt B. Sárosi, +6

ChemMedChem

Action at a Distance

Anna L. Blobaum, Shu Xu, Scott W. Rowlinson, +6

Journal of Biological Chemistry

CP-25 reverses prostaglandin E4 receptor desensitization-induced fibroblast-like synoviocyte dysfunction via the G protein-coupled receptor kinase 2 in autoimmune arthritis

Xiaoyi Jia, Yan Chang, Wei Fang, +8

Acta Pharmacologica Sinica

InflammationRheumatologyRheumatoid DisorderAutoimmune DiseaseG Protein-coupled Receptor +10

Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling

James A. Wepy, James J. Galligan, Philip J. Kingsley, +5

Journal of Lipid Research

A novel rabies vaccine based-on toll-like receptor 3 (TLR3) agonist PIKA adjuvant exhibiting excellent safety and efficacy in animal studies

Yi Zhang, Shoufeng Zhang, Wei Li, +10

Virology

VaccinationCross-protectionVaccine DevelopmentNovel RabiesVaccine Target +7

Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes

Matthew A. Windsor, Daniel Hermanson, Philip J. Kingsley, +7

ACS Medicinal Chemistry Letters

Achiral Profen ProbesPharmacotherapyChemical BiologyPharmaceutical ChemistryMolecular Pharmacology +15