Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils

Hector Huerga Encabo, Iker Valle Aramburu, Manuel Garcia‐Albornoz, +19

Cell stem cell

Triggering interferon signaling in T cells with avadomide sensitizes CLL to anti-PD-L1/PD-1 immunotherapy

Nikolaos Ioannou, Patrick R. Hagner, Matt Stokes, +18

Blood

Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma

Benedetta Apollonio, Filomena Spada, Nedyalko Petrov, +28

Journal of Clinical Investigation

Combination lenalidomide‐rituximab immunotherapy activates anti‐tumour immunity and induces tumour cell death by complementary mechanisms of action in follicular lymphoma

Hsiling Chiu, Preeti Trisal, Chad C. Bjorklund, +11

British Journal of Haematology

Tumor-Infiltrating Clonal Hematopoiesis

Oriol Pich, Elsa Bernard, Maria Zagorulya, +45

New England Journal of Medicine

Integrated epigenomic and transcriptomic analysis reveals <i>TP63</i> as a novel player in clinically aggressive chronic lymphocytic leukemia

Nikos Papakonstantinou, Stavroula Ntoufa, Maria Tsagiopoulou, +27

International Journal of Cancer

Epigenetic ChangeGeneticsDna MethylationImmunologyNovel Player +15

T-Cell Dynamics in Chronic Lymphocytic Leukemia under Different Treatment Modalities

Anna Vardi, Elisavet Vlachonikola, Despoina Papazoglou, +16

Clinical Cancer Research

Ibrutinib-based therapy reinvigorates CD8+ T cells compared to chemoimmunotherapy: immune monitoring from the E1912 trial

Despoina Papazoglou, Victoria Wang, Tait D. Shanafelt, +9

Blood

ImmunologyPathologyImmunotherapyTumor BiologyInflammation +19

Ibrutinib-Based Therapy Improves Anti-Tumor T Cell Killing Function Allowing Effective Pairing with Anti-PD-L1 Immunotherapy Compared to Traditional FCR Chemoimmunotherapy; Implications for Therapy and Correlative Immune Functional Data from the Phase III E1912 Trial

Despoina Papazoglou, Connie Lesnick, Victoria Wang, +3

Blood

The immunomodulatory molecule TIGIT is expressed by chronic lymphocytic leukemia cells and contributes to anergy

Francesca Arruga, Marta Rubin, Despoina Papazoglou, +13

Haematologica

T-regulatory CellImmunologyImmune RegulationTigit ExpressionImmunologic Mechanism +14