High Sp1/Sp3 Ratios in Epithelial Cells during Epithelial Differentiation and Cellular Transformation Correlate with the Activation of the HPV-16 Promoter

Doris Apt, Robin M. Watts, Guntram Suske, +1

Virology

Systems BiologyHpv-16 PromoterGene ExpressionVirus GeneCell Biology +3

The enhancer of human papillomavirus type 16: binding sites for the ubiquitous transcription factors oct-1, NFA, TEF-2, NF1, and AP-1 participate in epithelial cell-specific transcription

T Chong, Doris Apt, Bernd Gloss, +2

Journal of Virology

ImmunologyPathologyTumor BiologyCancer-associated VirusTranscriptional Regulation +22

Phase I Study of Apitolisib (GDC-0980), Dual Phosphatidylinositol-3-Kinase and Mammalian Target of Rapamycin Kinase Inhibitor, in Patients with Advanced Solid Tumors

Saoirse Dolly, Andrew J. Wagner, Johanna C. Bendell, +14

Clinical Cancer Research

Pictilisib PI3Kinase inhibitor (a phosphatidylinositol 3-kinase [PI3K] inhibitor) plus paclitaxel for the treatment of hormone receptor-positive, HER2-negative, locally recurrent, or metastatic breast cancer: interim analysis of the multicentre, placebo-controlled, phase II randomised PEGGY study

Peter Vuylsteke, Manon Huizing, Katarína Petráková, +10

Annals of Oncology

Metastatic Breast CancerBreast OncologyPhase IiMedicinePharmacology +7

Nuclear factor I and epithelial cell-specific transcription of human papillomavirus type 16

Doris Apt, T Chong, Yi Liu, +1

Journal of Virology

Viral ReplicationImmunologyPathologyHeterodimeric ComplexesCancer-associated Virus +17

Tetravalent neutralizing antibody response against four dengue serotypes by a single chimeric dengue envelope antigen

Doris Apt, Kanakatte Raviprakash, Alice Brinkman, +7

Vaccine

VaccinationImmunologyVirologyAntibody ResponseAntibody Engineering +7

Cloning and functional analysis of spliced isoforms of human nuclear factor I-X: interference with transcriptional activation by NFI/CTF in a cell-type specific manner

Doris Apt, Yichun Liu, Hans‐Ulrich Bernard

Nucleic Acids Research

A chimeric tetravalent dengue DNA vaccine elicits neutralizing antibody to all four virus serotypes in rhesus macaques

Kanakatte Raviprakash, Doris Apt, Alice Brinkman, +8

Virology

VaccinationVirus SerotypesVaccine DevelopmentRhesus MacaquesImmunology +4

NFI-B3, a Novel Transcriptional Repressor of the Nuclear Factor I Family, Is Generated by Alternative RNA Processing

Yichun Liu, Hans‐Ulrich Bernard, Doris Apt

Journal of Biological Chemistry

Diverse Plasmid DNA Vectors by Directed Molecular Evolution of Cytomegalovirus Promoters

Anne Wright, Andrey Semyonov, Glenn Dawes, +5

Human Gene Therapy