Brett M. Hirsch

Gain of Interaction with IRS1 by p110α-Helical Domain Mutants Is Crucial for Their Oncogenic Functions

Yujun Hao, Chao Wang, Bo Cao et al. · Cancer Cell · 2013 · 121 citations · Full text

Protein Function, Their Oncogenic Functions, Molecular Regulation +7

Substrate specificity of SIRT1-catalyzed lysine Nε-deacetylation reaction probed with the side chain modified Nε-acetyl-lysine analogs

Nuttara Jamonnak, Brett M. Hirsch, Yi Pang et al. · Bioorganic Chemistry · 2009 · 32 citations

Biochemistry, Nε-acetyl-lysine Analogs, Natural Sciences +7

A mechanism-based potent sirtuin inhibitor containing Nε-thiocarbamoyl-lysine (TuAcK)

Brett M. Hirsch, Yujun Hao, Xiaopeng Li et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 23 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Medicine +6

Discovery of potent, proteolytically stable, and cell permeable human sirtuin peptidomimetic inhibitors containing Nε-thioacetyl-lysine

Brett M. Hirsch, Caroline A. Gallo, Zhanwen Du et al. · MedChemComm · 2010 · 21 citations

Drug Target, Peptide Science, Pharmacotherapy +20

Selective Inhibitors of <i>Helicobacter pylori</i> Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase

Rajesh K. Harijan, Oskar Hoff, Rodrigo G. Ducati et al. · Journal of Medicinal Chemistry · 2019 · 18 citations · Full text

H. Pylori Mtan, Hpmtan Bind, Biosynthesis +13