Olga V. Leontieva

The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway

Lioubov G. Korotchkina, Olga V. Leontieva, Elena I. Bukreeva et al. · Aging · 2010 · 273 citations · Full text

Lifespan Extension, Aging, Cell Division +13

Hypoxia suppresses conversion from proliferative arrest to cellular senescence

Olga V. Leontieva, Venkatesh Natarajan, Zoya N. Demidenko et al. · Proceedings of the National Academy of Sciences · 2012 · 165 citations · Full text

Hypoxia Inhibits Mtor, Aging, Cell Death +20

DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence

Olga V. Leontieva, Mikhail V. Blagosklonny · Aging · 2010 · 156 citations · Full text

Dna Damage, Aging, Apoptosis +17

Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program

Olga V. Leontieva, Zoya N. Demidenko, Mikhail V. Blagosklonny · Proceedings of the National Academy of Sciences · 2014 · 152 citations · Full text

Molecular Biology, Cell Proliferation, Mtor Pathway +17

Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice

Elena A. Komarova, Marina P. Antoch, Liliya R. Novototskaya et al. · Aging · 2012 · 149 citations · Full text

Cell Death, Pathology, Mtor Pathway +17