Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth

Jaya Sangodkar, Abbey Perl, Rita Tohmé, +41

Journal of Clinical Investigation

Kras-driven Tumor GrowthCell ProliferationCancer BiologyTumor BiologyReceptor Tyrosine Kinase +16

Selective PP2A Enhancement through Biased Heterotrimer Stabilization

Daniel Léonard, Wei Huang, Sudeh Izadmehr, +16

Cell

Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer

Kimberly McClinch, Rita A. Avelar, David Callejas, +27

Cancer Research

Reengineered tricyclic anti-cancer agents

David B. Kastrinsky, Jaya Sangodkar, Nilesh Zaware, +4

Bioorganic & Medicinal Chemistry

Medicinal ChemistryMedicinePharmacologyPharmacotherapyAnti-cancer Agent +5

Single Agents with Designed Combination Chemotherapy Potential: Synthesis and Evaluation of Substituted Pyrimido[4,5-<i>b</i>]indoles as Receptor Tyrosine Kinase and Thymidylate Synthase Inhibitors and as Antitumor Agents

Aleem Gangjee, Nilesh Zaware, Sudhir Raghavan, +3

Journal of Medicinal Chemistry

Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies

Kanak Raina, Chris D. Forbes, Rebecca Stronk, +32

Cell chemical biology

Tumor BiologyDrug TargetingMedicineCancer Cell BiologyCancer Selective Therapies +11

AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization

Anja Bastian, Satoshi Matsuzaki, Kenneth M. Humphries, +5

Cancer Letters

Redox SignalingMolecular PharmacologyRedox RegulatorMedicineHypoxia (Medicine) +10

Monotherapy efficacy of blood–brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma

Joni Merisaari, Oxana V. Denisova, Milena Doroszko, +10

Brain Communications

Recent advances in dibenzo[ <i>b</i> , <i>f</i> ][1,4]oxazepine synthesis

Nilesh Zaware, Michael J. Ohlmeyer

Heterocyclic Communications

Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively

Kanak Raina, Chris D. Forbes, Rebecca Stronk, +29