Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress

Nam Hee Kim, Yong Hoon, Jueun Lee, +18

Nature Communications

Aldehyde dehydrogenase is used by cancer cells for energy metabolism

Joon Hee Kang, Seon-Hyeong Lee, Dongwan Hong, +10

Experimental & Molecular Medicine

Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner

Yoonmi Lee, Nam Hee Kim, Eunae Sandra Cho, +15

Nature Communications

Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion

Joon Hee Kang, Seon-Hyeong Lee, Jae‐Seon Lee, +7

Oncotarget

Aldo-keto ReductaseAldh IsoformsAldehyde Dehydrogenase InhibitionCell DeathRedox Biology +16

ATP Production Relies on Fatty Acid Oxidation Rather than Glycolysis in Pancreatic Ductal Adenocarcinoma

Jae‐Seon Lee, Soo Jin Oh, Hyun-Jung Choi, +7

Cancers

Atp Production ReliesMetabolic RemodelingMetabolic SyndromePancreatic CancerFatty Acids +18

Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC

Jae-Seon Lee, Joon Hee Kang, Seon-Hyeong Lee, +5

Cell Death and Disease

Loss of SLC25A11 causes suppression of NSCLC and melanoma tumor formation

Jae‐Seon Lee, Ho Lee, Soohyun Lee, +3

EBioMedicine

Targeting Oxidative Phosphorylation Reverses Drug Resistance in Cancer Cells by Blocking Autophagy Recycling

Jae-Seon Lee, Ho Lee, Hyonchol Jang, +7

Cells

Cell AutophagyMitophagyMtor Complex 1Mitochondrial FunctionBiochemistry +12

Gastric cancer depends on aldehyde dehydrogenase 3A1 for fatty acid oxidation

Jae‐Seon Lee, Seung Hwa Kim, Soohyun Lee, +4

Scientific Reports

Targeting Mitochondrial Oxidative Phosphorylation Abrogated Irinotecan Resistance in NSCLC

Soohyun Lee, Jae-Seon Lee, Jinho Seo, +4

Scientific Reports