Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis Models

Joel Chappell, Jennifer Harman, Vagheesh M. Narasimhan, +5

Circulation Research

Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels

Lina Dobnikar, Annabel L. Taylor, Joel Chappell, +7

Nature Communications

Integrated pseudotime analysis of human pre-implantation embryo single-cell transcriptomes reveals the dynamics of lineage specification

Dimitri Meistermann, Alexandre Bruneau, Sophie Loubersac, +23

Cell stem cell

Pseudotime AnalysisCell LineageDevelopmental BiologySingle Cell SequencingMedicine +10

Vascular Smooth Muscle Cell Plasticity and Autophagy in Dissecting Aortic Aneurysms

Marc Clément, Joel Chappell, Juliette Raffort, +10

Arteriosclerosis Thrombosis and Vascular Biology

Vascular DiseaseEngineeringAng IiBiomedical EngineeringCellular Physiology +18

The CXCL12/CXCR4 Axis Plays a Critical Role in Coronary Artery Development

Sarah Ivins, Joel Chappell, Bertrand Vernay, +4

Developmental Cell

Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells

Thi Xuan Ai Pham, Amitesh Panda, Harunobu Kagawa, +19

Cell stem cell

Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction

Dick W. Zijlmans, Irene Talón, Sigrid Verhelst, +33

Nature Cell Biology

Lineage PotentialEpigenetic ChangeGeneticsMolecular BiologyEpigenetics +20

Interleukin-6 is an activator of pituitary stem cells upon local damage, a competence quenched in the aging gland

Annelies Vennekens, Emma Laporte, Florian Hermans, +12

Proceedings of the National Academy of Sciences

Dynamic reversal of random X-Chromosome inactivation during iPSC reprogramming

Adrian Janiszewski, Irene Talón, Joel Chappell, +11

Genome Research

Histone ModificationsEpigenetic ChangeGeneticsGenomic MechanismMolecular Genetics +18

Epigenetic Regulation of Vascular Smooth Muscle Cells by Histone H3 Lysine 9 Dimethylation Attenuates Target Gene-Induction by Inflammatory Signaling

Jennifer Harman, Lina Dobnikar, Joel Chappell, +12

Arteriosclerosis Thrombosis and Vascular Biology