Mahan Gholam Azad

The thiosemicarbazone, DpC, broadly synergizes with multiple anti-cancer therapeutics and demonstrates temperature- and energy-dependent uptake by tumor cells

Mahendiran Dharmasivam, Mahan Gholam Azad, Rizwana Afroz et al. · Biochimica et Biophysica Acta (BBA) - General Subjects · 2022 · 31 citations · Full text

Energy-dependent Uptake, Drug Targeting, Medicine +9

Designing Tailored Thiosemicarbazones with Bespoke Properties: The Styrene Moiety Imparts Potent Activity, Inhibits Heme Center Oxidation, and Results in a Novel “Stealth Zinc(II) Complex”

Mahendiran Dharmasivam, Büşra Kaya, Tharushi P. Wijesinghe et al. · Journal of Medicinal Chemistry · 2023 · 31 citations · Full text

Isosteric Replacement of Sulfur to Selenium in a Thiosemicarbazone: Promotion of Zn(II) Complex Dissociation and Transmetalation to Augment Anticancer Efficacy

Büşra Kaya, Mahan Gholam Azad, Mediha Süleymanoğlu et al. · Journal of Medicinal Chemistry · 2024 · 24 citations · Full text

Chemistry, Pharmaceutical Chemistry, Redox Biology +16

Innovative thiosemicarbazones that induce multi-modal mechanisms to down-regulate estrogen-, progesterone-, androgen- and prolactin-receptors in breast cancer

Faten Shehadeh-Tout, Heloisa Milioli, Suraya Roslan et al. · Pharmacological Research · 2023 · 22 citations · Full text

Differential transmetallation of complexes of the anti-cancer thiosemicarbazone, Dp4e4mT: effects on anti-proliferative efficacy, redox activity, oxy-myoglobin and oxy-hemoglobin oxidation

Mahendiran Dharmasivam, Büşra Kaya, Tharushi P. Wijesinghe et al. · Chemical Science · 2023 · 20 citations · Full text