Cholangiocarcinomas can originate from hepatocytes in mice

Biao Fan, Yann Malato, Diego F. Calvisi, +8

Journal of Clinical Investigation

Tumor BiologyHepatologyLethal IccsBiliary TractLiver Physiology +12

Activation of β-Catenin and Yap1 in Human Hepatoblastoma and Induction of Hepatocarcinogenesis in Mice

Junyan Tao, Diego F. Calvisi, Sarangarajan Ranganathan, +12

Gastroenterology

Tumor BiologyHepatologyHuman HepatoblastomaMedicineLiver Physiology +8

Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma

Darjus F. Tschaharganeh, Xin Chen, Philipp Latzko, +20

Gastroenterology

Signaling PathwayHuman Hepatocellular CarcinomaMedicineLiver PhysiologyYes-associated Protein +8

A functional mammalian target of rapamycin complex 1 signaling is indispensable for c‐Myc‐driven hepatocarcinogenesis

Liu Pin, Meng-Meng Ge, Junjie Hu, +21

Hepatology

Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma

Ujjwal Mukund Mahajan, E Langhoff, Elisabetta Goni, +26

Gastroenterology

Stromal Signature AssociatedProgression-free SurvivalCancer ImmunosurveillancePancreatic CancerGastrointestinal Oncology +8

Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans

Li Che, Wenna Chi, Yu Qiao, +23

Gut

Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice

Shanshan Zhang, Xinhua Song, Dan Cao, +24

Journal of Hepatology

Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations

Adeola O. Adebayo Michael, Sungjin Ko, Junyan Tao, +22

Cell Metabolism

OncologyMedicinePharmacologyCancer Cell BiologyCancer Biology +7

Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans

Lei Li, Giulia M. Pilo, Xiaolei Li, +15

Journal of Hepatology

HepatologyLiver PhysiologyPathologyHepatotoxicityLiver Cancer +7

Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice

Junjie Hu, Li Che, Lei Li, +11

Scientific Reports