I. Can Kazan

Dynamic coupling of residues within proteins as a mechanistic foundation of many enigmatic pathogenic missense variants

Nicholas J. Ose, Brandon M. Butler, Avishek Kumar et al. · PLoS Computational Biology · 2022 · 41 citations · Full text

Protein Assembly, Genetics, Active Sites +18

Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity

Katherine E. Larrimore, I. Can Kazan, Latha Kannan et al. · Scientific Reports · 2017 · 38 citations · Full text

Coevolving residues inform protein dynamics profiles and disease susceptibility of nSNVs

Brandon M. Butler, I. Can Kazan, Avishek Kumar et al. · PLoS Computational Biology · 2018 · 22 citations · Full text

Conformational Dynamics, Protein Assembly, Structural Bioinformatics +21

Allosteric regulatory control in dihydrofolate reductase is revealed by dynamic asymmetry

I. Can Kazan, Jeremy H. Mills, S. Banu Ozkan · Protein Science · 2023 · 21 citations · Full text

Design of novel cyanovirin-N variants by modulation of binding dynamics through distal mutations

I. Can Kazan, Prerna Sharma, Mohammad Imtiazur Rahman et al. · eLife · 2022 · 20 citations · Full text

Engineering, Novel Cyanovirin-n Variants, Molecular Biology +20