Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense

Andrew W. Roberts, Chaekyun Kim, Ling Zhen, +10

Immunity

InflammationImmunohematologyDisease MechanismGranulocyteHematology +10

A Quantitative Nitroblue Tetrazolium Assay for Determining Intracellular Superoxide Anion Production in Phagocytic Cells

Hyung Sim Choi, Jun Woo Kim, Young‐Nam Cha, +1

Journal of Immunoassay and Immunochemistry

EngineeringNitric OxideLipid PeroxidationImmunologyPhagocytic Cells +20

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.

Daniel Williams, Feng‐Chun Yang, Chaekyun Kim, +13

PubMed

Fluoxetine affords robust neuroprotection in the postischemic brain via its anti‐inflammatory effect

Chaemoon Lim, Seung‐Woo Kim, Ju Young Park, +3

Journal of Neuroscience Research

Rac2 Is an Essential Regulator of Neutrophil Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation in Response to Specific Signaling Pathways

Chaekyun Kim, Mary C. Dinauer

The Journal of Immunology

Nadph OxidaseLipid PeroxidationImmunologyMolecular BiologySpecific Signaling Pathways +20

Rac2 Stimulates Akt Activation Affecting BAD/Bcl-XL Expression while Mediating Survival and Actin Function in Primary Mast Cells

Feng‐Chun Yang, Reuben Kapur, Alastair J. King, +7

Immunity

Primary Mast CellsCytokineMolecular PhysiologySignal TransductionCell Regulation +11

Rac2-Deficient Murine Macrophages Have Selective Defects in Superoxide Production and Phagocytosis of Opsonized Particles

Akira Yamauchi, Chaekyun Kim, Shijun Li, +4

The Journal of Immunology

CO from enhanced HO activity or from CORM-2 inhibits both O2− and NO production and downregulates HO-1 expression in LPS-stimulated macrophages

Klaokwan Srisook, Shan-Shu Han, Hyung-Sim Choi, +4

Biochemical Pharmacology

InflammationCytokineSignal TransductionBiochemistryAutophagy +10

Rap1a Null Mice Have Altered Myeloid Cell Functions Suggesting Distinct Roles for the Closely Related Rap1a and 1b Proteins

Yu Li, Jingliang Yan, Pradip De, +15

The Journal of Immunology

Inhibition of LPS-induced NO production by taurine chloramine in macrophages is mediated though Ras-ERK-NF-κB

Jun Woo Kim, Chaekyun Kim

Biochemical Pharmacology

InflammationLps-induced No ProductionAnti-inflammatoryAutoimmune DiseaseLung Inflammation +6