Bioorthogonal Removal of 3-Isocyanopropyl Groups Enables the Controlled Release of Fluorophores and Drugs in Vivo

Julian Tu, Minghao Xu, Saba Parvez, +2

Journal of the American Chemical Society

Pharmaceutical ScienceBioorganic ChemistryBioorthogonal RemovalChemical BiologyPharmaceutical Chemistry +14

Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles

Julian Tu, Dennis Svatunek, Saba Parvez, +6

Angewandte Chemie International Edition

T-REX on-demand redox targeting in live cells

Saba Parvez, Marcus J. C. Long, Hongyu Lin, +5

Nature Protocols

Cell-based Drug DeliveryT-rex On-demand RedoxRedox RegulatorImmunotherapyMedicine +3

MIC-Drop: A platform for large-scale in vivo CRISPR screens

Saba Parvez, Chelsea Herdman, Manu Beerens, +6

Science

EngineeringGeneticsDroplet MicrofluidicsBiomedical EngineeringMic-drop Screen +15

Substoichiometric Hydroxynonenylation of a Single Protein Recapitulates Whole-Cell-Stimulated Antioxidant Response

Saba Parvez, Yuan Fu, Jiayang Li, +5

Journal of the American Chemical Society

Lipid PeroxidationDiscrete RedoxMolecular BiologyRedox BiologyOxidative Stress +18

Akt3 is a privileged first responder in isozyme-specific electrophile response

Marcus J. C. Long, Saba Parvez, Yi Zhao, +4

Nature Chemical Biology

Molecular PhysiologySignal TransductionBiochemistryMolecular ResearchNatural Sciences +6

Temporally Controlled Targeting of 4-Hydroxynonenal to Specific Proteins in Living Cells

Xinqiang Fang, Yuan Fu, Marcus J. C. Long, +4

Journal of the American Chemical Society

Chemical BiologyOptogeneticsRedox BiologyHne DeliveryCell Signaling +18

Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups

Julian Tu, Dennis Svatunek, Saba Parvez, +5

Chemical Science

β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling

Marcus J. C. Long, Hongyu Lin, Saba Parvez, +4

Cell chemical biology

Signal TransductionSignaling PathwayMolecular RegulationVacillatory RegulatorCellular Regulatory Mechanism +5

Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera

Jesse R. Poganik, Kuan‐Ting Huang, Saba Parvez, +4

Nature Communications