Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers

Manaswini Sivaramakrishnan, Kathleen McCarthy, Sébastien Campagne, +26

Nature Communications

Identification of Novel Biomarker Candidates by Differential Peptidomics Analysis of Cerebrospinal Fluid in Alzheimers Disease

Hartmut Selle, Jens Lamerz, Katharina Büerger, +12

Combinatorial Chemistry & High Throughput Screening

Neurophysiological BiomarkersNeurochemical BiomarkersRobust BiomarkersAlzheimer's DiseaseCerebrospinal Fluid +19

Quantitative ADME Proteomics – CYP and UGT Enzymes in the Beagle Dog Liver and Intestine

Aki T. Heikkinen, Arno Friedlein, Mariette Matondo, +10

Pharmaceutical Research

Ugt EnzymesProteomic TechnologyProtein FunctionProtein ExpressionBiochemistry +7

Quantification of HER2 by Targeted Mass Spectrometry in Formalin-Fixed Paraffin-Embedded (FFPE) Breast Cancer Tissues

Carine Steiner, Jean‐Christophe Tille, Jens Lamerz, +8

Molecular & Cellular Proteomics

Factors Governing the Precision of Subvisible Particle Measurement Methods – A Case Study with a Low-Concentration Therapeutic Protein Product in a Prefilled Syringe

Anacelia Ríos Quiroz, Jens Lamerz, Thierry Da Cunha, +7

Pharmaceutical Research

EngineeringAnalytical InstrumentationMeasurementPrefilled SyringeBioanalysis +9

Mass Spectrometry-Based Quantification of CYP Enzymes to Establish In Vitro/In Vivo Scaling Factors for Intestinal and Hepatic Metabolism in Beagle Dog

Aki T. Heikkinen, Arno Friedlein, Jens Lamerz, +7

Pharmaceutical Research

Animal PhysiologyBiochemistryGastrointestinal PharmacologyLiver PhysiologyPhysiology +12

Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis

Sebastian Lugert, Thomas Kremer, Ravi Jagasia, +15

Scientific Reports

Development of a 5-plex SILAC Method Tuned for the Quantitation of Tyrosine Phosphorylation Dynamics

Manuel Tzouros, Sabrina Golling, David Ávila, +5

Molecular & Cellular Proteomics

Biophysical ModelingTyrosine Phosphorylation DynamicsChemical BiologySignaling PathwayReceptor Tyrosine Kinase +19

Multiple Protein Analysis of Formalin-fixed and Paraffin-embedded Tissue Samples with Reverse phase Protein Arrays

Maziar Assadi, Jens Lamerz, Tiantom Jarutat, +11

Molecular & Cellular Proteomics

EngineeringProtein AnalysisPathologyBiomedical EngineeringTumor Biology +23

In vivo profiling of DPP4 inhibitors reveals alterations in collagen metabolism and accumulation of an amyloid peptide in rat plasma

Marco Jost, Jens Lamerz, Harald Tammen, +10

Biochemical Pharmacology

Amyloid PeptideNeuropeptidesDpp4 InhibitorsBiochemistryMedicine +7