Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

Hiu Wing Cheung, Glenn S. Cowley, Barbara A. Weir, +27

Proceedings of the National Academy of Sciences

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

Glenn S. Cowley, Barbara A. Weir, Francisca Vázquez, +37

Scientific Data

Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria

Sara M. Nowinski, Ashley Solmonson, Scott Rusin, +16

eLife

Mammalian MitochondriaEnergy MetabolismMitochondrial BiogenesisBiochemistryMitochondrial Function +12

R-DeeP: Proteome-wide and Quantitative Identification of RNA-Dependent Proteins by Density Gradient Ultracentrifugation

Maïwen Caudron‐Herger, Scott Rusin, Mark E. Adamo, +5

Molecular Cell

Proteomic TechnologySystems BiologyDensity Gradient UltracentrifugationProtein FoldingNatural Sciences +11

Optimized Workflow for Multiplexed Phosphorylation Analysis of TMT-Labeled Peptides Using High-Field Asymmetric Waveform Ion Mobility Spectrometry

Devin K. Schweppe, Scott Rusin, Steven P. Gygi, +1

Journal of Proteome Research

Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins

Isha Nasa, Scott Rusin, Arminja N. Kettenbach, +1

Science Signaling

Identification of Candidate Casein Kinase 2 Substrates in Mitosis by Quantitative Phosphoproteomics

Scott Rusin, Mark E. Adamo, Arminja N. Kettenbach

Frontiers in Cell and Developmental Biology

Quantitative phosphoproteomics reveals new roles for the protein phosphatase PP6 in mitotic cells

Scott Rusin, Kate A. Schlosser, Mark E. Adamo, +1

Science Signaling

Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability

Ana Maria Dumitru, Scott Rusin, Amber E M Clark, +2

eLife

Kinetochore-microtubule Attachment StabilityMolecular RegulationGeneticsMolecular BiologyCytoskeleton +18

PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors

Meng S. Choy, Mark R. Swingle, Brandon D’Arcy, +6

Journal of the American Chemical Society

Drug TargetMolecular BiologySingle PppIndividual PppsChemical Biology +16