Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats.

Larry J. Black, Masahiko Sato, Ellen R. Rowley, +7

Journal of Clinical Investigation

Lipid PeroxidationGynecologyPharmacotherapyOsteoporosisOxidative Stress +18

Structure−Activity Relationships of Selective Estrogen Receptor Modulators:  Modifications to the 2-Arylbenzothiophene Core of Raloxifene

Timothy A. Grese, Stephen Cho, Don R. Finley, +15

Journal of Medicinal Chemistry

GynecologyRaloxifene AnalogsPharmacotherapyChemical BiologyPharmaceutical Chemistry +21

LY353381.HCl: A Novel Raloxifene Analog with Improved SERM Potency and Efficacy In Vivo

Masahiko Sato, Charles H. Turner, Tongyu Wang, +3

Journal of Pharmacology and Experimental Therapeutics

Synthesis and Pharmacology of Conformationally Restricted Raloxifene Analogues:  Highly Potent Selective Estrogen Receptor Modulators

Timothy A. Grese, Lewis D. Pennington, James P. Sluka, +13

Journal of Medicinal Chemistry

Abnormal Bone Architecture and Biomechanical Properties with Near-Lifetime Treatment of Rats with PTH

Masahiko Sato, John L. Vahle, Allen Schmidt, +4

Endocrinology

Abnormal Bone ArchitectureEngineeringPth Skeletal EffectsBiomechanical PropertiesBiomedical Engineering +16

LY353381·HCl: An Improved Benzothiophene Analog with Bone Efficacy Complementary to Parathyroid Hormone-(1–34)

Masahiko Sato, George Q. Zeng, Ellen R. Rowley, +1

Endocrinology

EngineeringOrganic ChemistryPharmacotherapyParathyroid GlandOsteoporosis +20

Raloxifene and Vitamin K2 Combine to Improve the Femoral Neck Strength of Ovariectomized Rats

Jun Iwamoto, J. K. Yeh, Allen Schmidt, +4

Calcified Tissue International

Bone DiseaseMedicineOsteoarthritisBone MetabolismOvariectomized Rats +7

Effects of Prolonged Ethinyl Estradiol Treatment on Calcium Channel Binding and In Vivo Calcium-Mediated Hemodynamic Responses in Ovariectomized Rats

Nancy Bowling, William E. Bloomquist, Marlene L. Cohen, +5

Journal of Pharmacology and Experimental Therapeutics

Benzopyran selective estrogen receptor modulators (SERMs): Pharmacological effects and structural correlation with raloxifene

Timothy A. Grese, James P. Sluka, Henry U. Bryant, +5

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryStructural CorrelationPharmacological StudyMedicineHormonal Receptor +8

Synthesis and pharmacology of 2-alkyl raloxifene analogs

Timothy A. Grese, Stephen Cho, Henry U. Bryant, +6

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceMedicineNatural SciencesPharmacological Agent +6