Cell-Cycle Reprogramming for PI3K Inhibition Overrides a Relapse-Specific C481S <i>BTK</i> Mutation Revealed by Longitudinal Functional Genomics in Mantle Cell Lymphoma

David Chiron, Maurizio Di Liberto, Peter Martin, +14

Cancer Discovery

A Novel Therapeutic Combination Using PD 0332991 and Bortezomib: Study in the 5T33MM Myeloma Model

Eline Menu, Josefina García, Xiangao Huang, +5

Cancer Research

Prolonged early G1 arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle–coupled loss of IRF4

Xiangao Huang, Maurizio Di Liberto, David Jayabalan, +12

Blood

MAGE-A Inhibits Apoptosis in Proliferating Myeloma Cells through Repression of Bax and Maintenance of Survivin

Tricia Nardiello, Achim A. Jungbluth, Anna Mei, +14

Clinical Cancer Research

A phase 1 trial of ibrutinib plus palbociclib in previously treated mantle cell lymphoma

Peter Martin, Nancy L. Bartlett, Kristie A. Blum, +11

Blood

Induction of prolonged early G₁arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1

David Chiron, Peter Martin, Maurizio Di Liberto, +6

Cell Cycle

Selective InhibitionCancer ResearchLymphoid NeoplasiaSignaling PathwayCell Regulation +13

Phase 1/2 study of cyclin-dependent kinase (CDK)4/6 inhibitor palbociclib (PD-0332991) with bortezomib and dexamethasone in relapsed/refractory multiple myeloma

Rubén Niesvizky, Ashraf Badros, Luciano J. Costa, +20

Leukemia & lymphoma/Leukemia and lymphoma

CDK4/6 Inhibitor PD 0332991 Sensitizes Acute Myeloid Leukemia to Cytarabine-Mediated Cytotoxicity

Chenyi Yang, Cynthia A. Boyson, Maurizio Di Liberto, +6

Cancer Research

Mixed-phenotype Acute LeukemiaApoptosisImmunologyCell DeathImmunotherapy +15

Homeostatic cell-cycle control by BLyS: Induction of cell-cycle entry but not G₁/S transition in opposition to p18^INK4cand p27^Kip1

Xiangao Huang, Maurizio Di Liberto, Adam F. Cunningham, +6

Proceedings of the National Academy of Sciences

A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function

Yaobin Liu, Xiangao Huang, Xian He, +5

The FASEB Journal