Mutation of the c-Cbl TKB Domain Binding Site on the Met Receptor Tyrosine Kinase Converts It into a Transforming Protein

Pascal Peschard, Tanya M. Fournier, Louie Lamorte, +4

Molecular Cell

Transforming ProteinSignal TransductionSignaling PathwayReceptor Tyrosine KinaseReceptor (Biochemistry) +4

Escape from Cbl-mediated downregulation

Pascal Peschard, Morag Park

Cancer Cell

Cannabis UseMedicineCbl-mediated DownregulationPharmacotherapyPharmacology +1

Met/Hepatocyte Growth Factor Receptor Ubiquitination Suppresses Transformation and Is Required for Hrs Phosphorylation

Jasmine V. Abella, Pascal Peschard, Monica A. Naujokas, +4

Molecular and Cellular Biology

Met InternalizationHrs PhosphorylationMet ReceptorCellular PhysiologyTumor Biology +16

Structural Basis for Ubiquitin-Mediated Dimerization and Activation of the Ubiquitin Protein Ligase Cbl-b

Pascal Peschard, Guennadi Kozlov, Lin Tong, +5

Molecular Cell

Protein FunctionUbiquitin-mediated DimerizationMolecular BiologyStructural BasisMolecular Basis +2

A Conserved DpYR Motif in the Juxtamembrane Domain of the Met Receptor Family Forms an Atypical c-Cbl/Cbl-b Tyrosine Kinase Binding Domain Binding Site Required for Suppression of Oncogenic Activation

Pascal Peschard, Noboru Ishiyama, Lin Tong, +2

Journal of Biological Chemistry

Genetic Deletion of RALA and RALB Small GTPases Reveals Redundant Functions in Development and Tumorigenesis

Pascal Peschard, Afshan McCarthy, Valérie Leblanc-Dominguez, +4

Current Biology

Developmental BiologyCell RegulationGeneticsMolecular GeneticsCancer Genetics +6

The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis

Caroline Saucier, Hanane Khoury, Ka‐Man Venus Lai, +8

Proceedings of the National Academy of Sciences

RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes

Joel Johansson, Máté Nászai, Michael C. Hodder, +9

Cell stem cell

Oncogenic activation of the Met receptor tyrosine kinase fusion protein, Tpr–Met, involves exclusion from the endocytic degradative pathway

Hannah Mak, Pascal Peschard, Tao Lin, +3

Oncogene

Signal TransductionOncogenic ActivationSignaling PathwayCell RegulationReceptor Tyrosine Kinase +7

RalA promotes a direct exocyst-Par6 interaction to regulate polarity in neuronal development

Amlan Das, Sangeetha Gajendra, Katarzyna Falenta, +8

Journal of Cell Science

Brain DevelopmentCell PolarizationOptogeneticsCellular NeurobiologySocial Sciences +15