Sean R. Marcsisin

The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

Brandon Pybus, Sean R. Marcsisin, Xiannu Jin et al. · Malaria Journal · 2013 · 184 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations

Xiannu Jin, ThuLan Luong, Necole Reese et al. · Journal of Pharmacological and Toxicological Methods · 2014 · 109 citations

Pharmacy, Pharmacology, Drug Discovery +10

Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds

Sean R. Marcsisin, Jason Sousa, Gregory A. Reichard et al. · Malaria Journal · 2014 · 85 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Differential CYP 2D6 Metabolism Alters Primaquine Pharmacokinetics

Brittney Potter, Lisa H. Xie, Chau Vuong et al. · Antimicrobial Agents and Chemotherapy · 2015 · 78 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation

Sean C. Murphy, Elizabeth R. Duke, Kelly J. Shipman et al. · The Journal of Infectious Diseases · 2017 · 61 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +13