Vaccine-like Controlled-Release Delivery of an Immunomodulating Peptide To Treat Experimental Autoimmune Encephalomyelitis

Barlas Büyüktimkin, Qun Wang, Paul Kiptoo, +3

Molecular Pharmaceutics

Enhancement of Drug Absorption through the Blood−Brain Barrier and Inhibition of Intercellular Tight Junction Resealing by E-Cadherin Peptides

Paul Kiptoo, Ernawati Sinaga, Anna Maria Calcagno, +4

Molecular Pharmaceutics

Cell AdhesionCellular PharmacologyPeptide ScienceBiomedical EngineeringCell Junctions +22

Modulation of Blood–Brain Barrier Permeability in Mice Using Synthetic E-Cadherin Peptide

Ngoc On, Paul Kiptoo, Teruna J. Siahaan, +1

Molecular Pharmaceutics

Modulation of Intercellular Junctions by Cyclic-ADT Peptides as a Method to Reversibly Increase Blood–Brain Barrier Permeability

Marlyn Dian Laksitorini, Paul Kiptoo, Ngoc On, +3

Journal of Pharmaceutical Sciences

Cyclic-adt PeptidesNeurophysiologyBlood–brain BarrierPhysiologyVascular Biology +6

Enhancement of transdermal delivery of 6-β-naltrexol via a codrug linked to hydroxybupropion

Paul Kiptoo, Mohamed O. Hamad, Peter A. Crooks, +1

Journal of Controlled Release

Transdermal DeliveryPolymer-drug ConjugateMedicinePharmaceutical TechnologyDrug Delivery Systems +3

Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6β-naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents

Mohamed O. Hamad, Paul Kiptoo, Audra L. Stinchcomb, +1

Bioorganic & Medicinal Chemistry

Pharmaceutical SciencePotential Alcohol AbuseBiochemistryMedicineHydrolytic Behavior +4

Transdermal Delivery of Naltrexone and its Active Metabolite 6-β-Naltrexol in Human Skin in Vitro and Guinea Pigs in Vivo

Kalpana S. Paudel, Buchi N. Nalluri, Dana C. Hammell, +5

Journal of Pharmaceutical Sciences

Transdermal DeliveryPharmacological StudyGuinea PigsMedicineTopical Drug +6

Comparison of Linear and Cyclic His-Ala-Val Peptides in Modulating the Blood-Brain Barrier Permeability: Impact on Delivery of Molecules to the Brain

Ahmed L. Alaofi, Ngoc On, Paul Kiptoo, +3

Journal of Pharmaceutical Sciences

NeuropeptidesBlood–brain BarrierNeurophysiologyMedicinePeptide Engineering +10

Prophylactic and therapeutic suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor

Naoki Kobayashi, Paul Kiptoo, Hitomi Kobayashi, +3

Clinical Immunology

Therapeutic SuppressionAutoimmune DiseaseMedicineImmunologyExperimental Autoimmune Encephalomyelitis +9

Improving Brain Delivery of Biomolecules via BBB Modulation in Mouse and Rat: Detection using MRI, NIRF, and Mass Spectrometry

Kavisha R. Ulapane, Ngoc On, Paul Kiptoo, +3

Nanotheranostics