Sodium glucose cotransporter 2 inhibitor canagliflozin attenuates liver cancer cell growth and angiogenic activity by inhibiting glucose uptake

Kosuke Kaji, Norihisa Nishimura, Kenichiro Seki, +9

International Journal of Cancer

Leptin‐mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats†

Mitsuteru Kitade, Hitoshi Yoshiji, Hideyuki Kojima, +12

Hepatology

Dipeptidyl peptidase-4 inhibitor attenuates hepatic fibrosis via suppression of activated hepatic stellate cell in rats

Kosuke Kaji, Hitoshi Yoshiji, Yasuhide Ikenaka, +11

Journal of Gastroenterology

Liver FibrosisPathologyHepatic FibrosisCirrhosisInflammation +14

Progressive Loss of the Proliferative Response of Senescing Wi-38 Cells to Platelet-derived Growth Factor, Epidermal Growth Factor, Insulin, Transferrin, and Dexamethasone

Paul D. Phillips, Kosuke Kaji, Vincent J. Cristofalo

Journal of Gerontology

Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling

Mitsuteru Kitade, Valentina M. Factor, Jesper B. Andersen, +10

Genes & Development

Specific Fate DecisionsCell ProliferationCholangiopathiesCholangiocyte BiologyHpc Self-renewal +19

Rifaximin ameliorates hepatic encephalopathy and endotoxemia without affecting the gut microbiome diversity

Kosuke Kaji, Hiroaki Takaya, Soichiro Saikawa, +9

World Journal of Gastroenterology

Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma

Hitoshi Yoshiji, Ryuichi Noguchi, Masahisa Toyohara, +13

Journal of Hepatology

OncologyHepatologyHepatocellular CarcinomaVitamin K2Liver Physiology +8

Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway

Koji Ishida, Kosuke Kaji, Shinya Sato, +8

The Journal of Nutritional Biochemistry

InflammationAcetaldehyde MetabolizationHepatologyBiochemistryMedicine +12

Gut dysbiosis associated with clinical prognosis of patients with primary biliary cholangitis

Masanori Furukawa, Kei Moriya, Jiro Nakayama, +18

Hepatology Research

Reduction of endotoxin attenuates liver fibrosis through suppression of hepatic stellate cell activation and remission of intestinal permeability in a rat non-alcoholic steatohepatitis model

Akitoshi Douhara, Kei Moriya, Hitoshi Yoshiji, +10

Molecular Medicine Reports

Intestinal PermeabilityLiver FibrosisDysbiosisMicrobial PathogensImmunology +27