Discovery of Novel Human Histamine H4 Receptor Ligands by Large-Scale Structure-Based Virtual Screening

Róbert Kiss, Béla Kiss, Árpád Könczöl, +6

Journal of Medicinal Chemistry

Molecular DockingMolecular RecognitionVirtual HitsVirtual ScreeningHit Identification +12

Applicability of a Blood–Brain Barrier Specific Artificial Membrane Permeability Assay at the Early Stage of Natural Product-Based CNS Drug Discovery

Árpád Könczöl, Judit Müller, Emília Földes, +4

Journal of Natural Products

Tuning the predictive capacity of the PAMPA-BBB model

Judit Müller, Katalin Esső, Gergő Dargó, +2

European Journal of Pharmaceutical Sciences

EngineeringPredictive AnalyticsManagementPredictive ModelingPredictability +4

First characterisation of flavonoid- and diarylheptanoid-type antioxidant phenolics in Corylus maxima by HPLC-DAD-ESI-MS

Eszter Riethmüller, Gergő Tóth, Ágnes Alberti, +5

Journal of Pharmaceutical and Biomedical Analysis

Diarylheptanoid-type Antioxidant PhenolicsBiochemistryMedicineFirst CharacterisationCorylus Maxima +5

Nitrone derivatives of trolox as neuroprotective agents

György Tibor Balogh, Krisztina Vukics, Árpád Könczöl, +2

Bioorganic & Medicinal Chemistry Letters

Nitrone DerivativesMedicinePharmacological AgentNeuroprotectionPharmacology +1

Blood-brain barrier specific permeability assay reveals N -methylated tyramine derivatives in standardised leaf extracts and herbal products of Ginkgo biloba

Árpád Könczöl, Kata Rendes, Miklós Dékány, +3

Journal of Pharmaceutical and Biomedical Analysis

Standardised Leaf ExtractsMedicineHerbal MedicineHerb-drug InteractionTyramine Derivatives +8

BBB penetration-targeting physicochemical lead selection: Ecdysteroids as chemo-sensitizers against CNS tumors

Judit Müller, Ana Martins, József Csábi, +4

European Journal of Pharmaceutical Sciences

NanomedicineMedicinal ChemistryDrug TargetingEngineeringTheranostics +6

Three newly identified lipophilic flavonoids in Tanacetum parthenium supercritical fluid extract penetrating the Blood-Brain Barrier

Krisztina Végh, Eszter Riethmüller, Levente Hosszú, +8

Journal of Pharmaceutical and Biomedical Analysis

Medicinal ChemistryPolyphenolicsBiochemistryMedicineNatural Sciences +7

Continuous Industrial-Scale Centrifugal Partition Chromatography with Automatic Solvent System Handling: Concept and Instrumentation

László Lorántfy, Dóra Rutterschmid, Róbert Örkényi, +4

Organic Process Research & Development

Solvent ExtractionEngineeringCpc SeparationsPreparative ApplicationCpc Operation +14

pH-gradient PAMPA-based in vitro model assay for drug-induced phospholipidosis in early stage of drug discovery

György Tibor Balogh, Judit Müller, Árpád Könczöl

European Journal of Pharmaceutical Sciences

Drug-induced PhospholipidosisProteinlipid InteractionLipid PreparationBiochemistryMedicine +6