21:I[432972,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/30036bedc5269936.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/cd5e572bc3e4eb92.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/d4ac9dcf27f6ff52.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 22:T54e,To study the geographical distribution and mortality of primary liver cancer (PLC) in China from 1990 through 1992.A death survey among one tenth of Chinese population was conducted in 1990-1992 and the data on PLC mortality were analyzed.The crude mortality for PLC was 20.4 per 100,000 population (29.0 per 100,000 for males and 11.2 per 100,000 for females), accounted for 18.8% of the total cancer deaths in 1990-1992. In China, PLC mortality ranked second after stomach cancer. The age-standardized mortality rate (adjusted by the world population) of male Chinese was 33.7 per 100,000 which was 2. 2 times as high as that of male Japanese and 4.6 times as high as that of male Italian. The age-standardized rate of female Chinese was 12.3 per 100,000 which was 3.1 and 5.1 times as high compared to female Japanese and female Italian, respectively. PLC occurred in every age group but the mortality rate was highest in the age group of 30-44 years. The mortality was slightly higher in the rural than in the urban population. The cumulative death rate in the urban population was 3.5% for males and 1.2% for females, while that in the rural population was 4.1% for males and 1.6% for females. PLC showed geographical clustering along the south-east coast of China.To prevent primary liver cancer remains to be the major task of cancer control in China.23:T51e,Aberrant activation of the WNT/β-catenin signaling pathway is implicated in various types of cancers. Inhibitors targeting the Wnt signaling pathway are intensively studied in the current cancer research field, the outcomes of which remain to be determined. In this study, we have attempted to discover novel potent WNT/β-catenin pathway inhibitors through tankyrase 1/2 structure-based virtual screening. After screening more than 13.4 million compounds through molecular docking, we experimentally verified one compound, LZZ-02, as the most potent inhibitor out of 11 structurally representative top hits. LiCl-induced HEK293 cells containing TOPFlash reporter showed that LZZ-02 inhibited the transcriptional activity of β-catenin with an IC₅₀ of 10 ± 1.2 μM. Mechanistically, LZZ-02 degrades the expression of β-catenin by stabilizing axin 2, thereby diminishing downstream proteins levels, including c-Myc and cyclin D1. LZZ-02 also inhibits the growth of colonic carcinoma cell harboring constitutively active β-catenin. More importantly, LZZ-02 effectively shrinks tumor xenograft derived from colonic cell lines. Our study successfully identified a novel tankyrase 1/2 inhibitor and shed light on a novel strategy for developing inhibitors targeting the WNT/β-catenin signaling axis.24:T47c,Lung cancer is the leading cause of cancer-related deaths worldwide. However, tumor suppressor genes remain to be systemically determined for lung cancer. Here we report interferon regulatory factor 8 (IRF8), a member of the IRF family of transcription factors, as a potent lung tumor suppressor gene. Expression of IRF8 is frequently diminished in lung tumoral tissues and is associated with prognosis of non-small cell lung cancer (NSCLC) patients. Ectopic expression of IRF8 suppresses the NSCLC cells proliferation in vitro and tumorigenic potential in vivo. More importantly, forced expression of IRF8 through infection of recombinant virus inhibits lung tumorigenesis in genetically engineered mouse model (GEMM). Mechanistically, IRF8 inhibits AKT signaling and promotes accumulation o

#	Concept	H-Index	Publications	Citations
1	Medicine	4	4	96
2	Natural Sciences	1	1	26
3	Public Health	1	1	37
4	Biochemistry	1	1	26
5	Cell Biology	1	1	23

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