Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk

Daniel Richard, Zun Liu, Jiaxue Cao, +17

Cell

Musculoskeletal ResearchGeneticsBiomechanicsEvolutionary BiologyCartilage Degeneration +7

Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses

Arinjay Banerjee, Nader El-Sayes, Patrick Budylowski, +25

iScience

Epigenetic profiling of growth plate chondrocytes sheds insight into regulatory genetic variation influencing height

Michael H. Guo, Zun Liu, Jessie Willen, +6

eLife

Disagreement on foundational principles of biological aging

Vadim N. Gladyshev, Benjamin Anderson, Hanna Barlit, +78

PNAS Nexus

Joint disease-specificity at the regulatory base-pair level

Pushpanathan Muthuirulan, Dewei Zhao, Mariel Young, +16

Nature Communications

The developmental impacts of natural selection on human pelvic morphology

Mariel Young, Daniel Richard, Mark Grabowski, +10

Science Advances

FertilityGeneticsNatural SelectionSexual SelectionAnatomy +19

Lineage-specific differences and regulatory networks governing human chondrocyte development

Daniel Richard, Steven Pregizer, Divya Venkatasubramanian, +5

eLife

Articular ChondrocytesGeneticsChondrogenesisEpigeneticsEmbryology +16

Rainbow trout exposed to benzo[a]pyrene yields conserved microRNA binding sites in DNA methyltransferases across 500 million years of evolution

Christopher Kuc, Daniel Richard, Samantha T. Johnson, +4

Scientific Reports

Functional genomics of human skeletal development and the patterning of height heritability

Daniel Richard, Pushpanathan Muthuirulan, Mariel Young, +6

Cell

Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals

Evelyn Jagoda, Davide Marnetto, Gayani Senevirathne, +10

eLife