Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing

Shin‐Heng Chiou, Ian P. Winters, Jing Wang, +14

Genes & Development

MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans

Claire Hughes, Leonardo Guasti, Eirini Meimaridou, +6

Journal of Clinical Investigation

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer

Adrián Vallejo, Naiara Perurena, Elizabeth Guruceaga, +20

Nature Communications

A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo

Zoe Rogers, Christopher D. McFarland, Ian P. Winters, +4

Nature Methods

Tumor BiologyTumor HeterogeneityMedicineTumor SuppressionCancer Genomics +11

An Arntl2-Driven Secretome Enables Lung Adenocarcinoma Metastatic Self-Sufficiency

Jennifer J. Brady, Chen-Hua Chuang, Peyton Greenside, +8

Cancer Cell

MedicineCancer BiologyCell BiologyCell SignalingLung Cancer +1

Incremental Genetic Perturbations to MCM2-7 Expression and Subcellular Distribution Reveal Exquisite Sensitivity of Mice to DNA Replication Stress

Chen-Hua Chuang, Marsha D. Wallace, Christian M. Abratte, +2

PLoS Genetics

Female-biased embryonic death from inflammation induced by genomic instability

Adrian J. McNairn, Chen-Hua Chuang, Jordana C. Bloom, +2

Nature

Axon-like protrusions promote small cell lung cancer migration and metastasis

Dian Yang, Fangfei Qu, Hongchen Cai, +9

eLife

Developmental BiologySclc CellsMedicineHuman Sclc CellsCancer Cell Biology +11

<i>miR-200</i> deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts

Bin Xue, Chen-Hua Chuang, Haydn M. Prosser, +14

Genes & Development

Lung AdenocarcinomaCancer-associated FibroblastsLung Adenocarcinoma MetastasisCancer BiologyTumor Biology +15

AMG 193, a Clinical Stage MTA-Cooperative PRMT5 Inhibitor, Drives Antitumor Activity Preclinically and in Patients with MTAP-Deleted Cancers

Brian Belmontes, Katherine K. Slemmons, Chun Su, +38

Cancer Discovery